RGS4 - regulator of G protein signaling 4 Gene

中文名称：G 蛋白信号调节器 4

种属: Homo sapiens

同用名: RGP4; SCZD9

基因 ID: 5999 | 基因类型: protein coding

关于 RGS4

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:163,068,871-163,076,802 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 23 paralogues. Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue.

功能概要

蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节子 4 属于该家族。所有 RGS 蛋白都共享一个保守的 120 个氨基酸序列，称为 RGS 结构域。 G 蛋白信号调节器 4 蛋白与 RGS1 的同一性为 37%，与大鼠 RGS4 的同一性为 97%。该蛋白在异源三聚体 G 蛋白的上游或水平负向调节信号传导，并定位于细胞质中。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat RGS4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

RGS4 基因产物(4)

mRNA	Protein	Name
NM_005613.6	NP_005604.1	regulator of G-protein signaling 4 isoform 2
NM_001102445.3	NP_001095915.1	regulator of G-protein signaling 4 isoform 1
NM_001113381.1	NP_001106852.1	regulator of G-protein signaling 4 isoform 4
NM_001113380.1	NP_001106851.1	regulator of G-protein signaling 4 isoform 3

基因本体论

细胞组分

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10791963	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10791963	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGS4 蛋白结构

RGS

0
100
205 a.a.

蛋白主名

其他名称

regulator of G-protein signaling 4

schizophrenia disorder 9

关联疾病

疾病名称

别名

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13509	CCG-50014	Inhibitor	99.42%	否
HY-U00431	CCG 203769	Inhibitor	99.76%	否
HY-70074	CCG-63802	Inhibitor	98.83%	否
HY-110054	CCG-2046	Inhibitor	/	否
HY-122251	CCG-4986	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RGS4	VGNC	VGNC:76690
Felis catus	RGS4	VGNC	VGNC:64596
Rattus norvegicus	RGS4	RGD	RGD:3567
Canis familiaris	RGS4	VGNC	VGNC:45534
Bos taurus	RGS4	VGNC	VGNC:54394
Mus musculus	RGS4	MGD	MGI:108409

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