AFAP1 - actin filament associated protein 1 Gene

中文名称：肌动蛋白丝相关蛋白 1

种属: Homo sapiens

同用名: AFAP; AFAP110; AFAP-110

基因 ID: 60312 | 基因类型: protein coding

关于 AFAP1

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,758,713-7,939,861 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 8.4), placenta (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码的蛋白质是 Src 结合伙伴。它可能代表响应细胞信号的肌动蛋白丝完整性的潜在调节剂，并且可以通过将 Src 家族成员和/或其他信号蛋白连接到肌动蛋白丝来充当衔接蛋白。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 8 月]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or Other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

AFAP1 基因产物(4)

mRNA	Protein	Name
NM_001134647.2	NP_001128119.1	actin filament-associated protein 1 isoform A
NM_001371090.1	NP_001358019.1	actin filament-associated protein 1 isoform B
NM_001371091.1	NP_001358020.1	actin filament-associated protein 1 isoform B
NM_198595.3	NP_940997.1	actin filament-associated protein 1 isoform B

AFAP1 蛋白结构

0
200
400
600
730 a.a.

蛋白主名

其他名称

actin filament-associated protein 1

110 kDa actin filament-associated protein

关联疾病

疾病名称

别名

Familial Adenomatous Polyposis 2

Mutyh-Related Attenuated Familial Adenomatous Polyposis	FAP2
Colorectal Adenomatous Polyposis, Autosomal Recessive	Adenomas, Multiple Colorectal
Mutyh-Associated Polyposis	Mutyh-Related Attenuated Familial Polyposis Coli
Mutyh-Related Attenuated Fap	Adenomas, Multiple Colorectal, Autosomal Recessive
Mutyh-Related Afap	Adenomas Multiple Colorectal Autosomal Recessive
Colorectal Adenomatous Polyposis Autosomal Recessive	Adenomatous Polyposis, Familial, Type 2

Desmoid Tumor

Aggressive Fibromatosis	Desmoid Type Fibromatosis
Familial Infiltrative Fibromatosis	Desmoid Disorder, Hereditary
Fif	Fibromatosis, Familial Infiltrative
Deep Fibromatosis	Desmoid Fibromatosis
Hereditary Desmoid Disease	Musculoaponeurotic Fibromatosis
Desmoid-Type Fibromatosis	Fibromatosis, Aggressive
Desmoid Disease, Hereditary	Musculo-Aponeurotic Fibromatosis

Juvenile Polyposis Syndrome

JPS	Juvenile Intestinal Polyposis
Jip	Pji
Juvenile Gastrointestinal Polyposis	Juvenile Polyposis
Polyposis, Juvenile Intestinal	Polyposis, Familial, Of Entire Gastrointestinal Tract
Polyposis Familial Of Entire Gastrointestinal Tract	Polyposis Juvenile Intestinal
Polyposis Syndrome, Juvenile

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Glaucoma, Normal Tension

Low Tension Glaucoma	Glaucoma, Normal Tension, Susceptibility To
Normal Tension Glaucoma	Ntg
Glaucoma, Normal Pressure	NPG
Glaucoma, Normal Pressure, Susceptibility To	Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Muir-Torre Syndrome

MRTES	Keratoacanthoma
Muir-Torré Syndrome	Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas
Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas	Multiple Keratoacanthoma, Muir-Torre Type
Mts	Torre-Muir Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00425	AFAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00426	AFAP1L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	AFAP1	VGNC	VGNC:37683
Mus musculus	AFAP1	MGD	MGI:1917542
Rattus norvegicus	AFAP1	RGD	RGD:619959
Bos taurus	AFAP1	VGNC	VGNC:25706
Macaca mulatta	AFAP1	VGNC	VGNC:100199
Felis catus	AFAP1	VGNC	VGNC:59665

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AFAP1 - actin filament associated protein 1 Gene

关于 AFAP1

功能概要

AFAP1 基因产物(4)

AFAP1 蛋白结构

关联疾病

直系同源

热门区域

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AFAP1 - actin filament associated protein 1 Gene

关于 AFAP1

功能概要

AFAP1 基因产物(4)

AFAP1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z