Cd274 - CD274 antigen Gene

中文名称：CD274 抗原

种属: Mus musculus

同用名: B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

关于 Cd274

功能概要

该基因编码的蛋白质是一种免疫抑制受体配体，由造血和非造血细胞表达，如T细胞和B细胞以及各种类型的肿瘤细胞。编码的蛋白质是一种 I 型跨膜蛋白，具有免疫球蛋白 V 样和 C 样结构域。该配体与其受体的相互作用抑制 T 细胞活化和细胞因子产生。在正常组织感染或炎症期间，这种相互作用对于通过维持免疫反应的稳态来预防自身免疫很重要。在肿瘤微环境中，这种相互作用通过细胞毒性 T 细胞失活为肿瘤细胞提供免疫逃逸。缺乏该基因的小鼠表现出多种表型，包括同种异体胎儿存活率降低和严重的实验性自身免疫性脑脊髓炎。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During Infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]