PD-L1 蛋白, Mouse (HEK293, His-Fc)

PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance. This interaction modulates T cell activation, limits effector responses and may stimulate IL10-producing T cell subsets. PD-L1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived PD-L1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

PD-L1 蛋白作为抑制性受体 PDCD1/PD-1 的配体，在维持自身免疫耐受方面发挥着至关重要的作用。这种相互作用调节 T 细胞的激活阈值，限制其效应反应，并可能刺激产生白细胞介素 10 (IL10) 的 T 细胞亚群。然而，肿瘤利用PDCD1介导的抑制途径来减弱抗肿瘤免疫力并逃避免疫系统的破坏，从而促进肿瘤存活。PD-L1 和 PDCD1/PD-1 之间的相互作用会抑制细胞毒性 T 淋巴细胞 (CTL) 的功能，但阻断该通路可以逆转耗尽的 T 细胞表型并使抗肿瘤反应正常化，为癌症免疫治疗提供了一种有前景的策略。

Measured by its ability to bind mouse PD-1 in functional ELISA.

Mouse

HEK293

C-hFc;C-His

Q9EP73 (F19-T238)

60533  [NCBI]

64-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.