2. Gene
  3. Acaca - acetyl-CoA carboxylase alpha Gene

Acaca - acetyl-CoA carboxylase alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：乙酰辅酶 A 羧化酶 α

种属: Rattus norvegicus

同用名: ACC1; Acac

基因 ID: 60581 | 基因类型: protein coding

关于 Acaca

Primary_assembly 10: 69,014,170-69,276,457 forward strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 12 phenotypes. Biased expression in Adrenal (RPKM 596.3), Thymus (RPKM 517.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动乙酰辅酶 A 羧化酶活性；生物素结合活性；和激酶结合活性。参与脂肪酸生物合成过程；对有机环状化合物的反应；和对外来刺激的反应。预计位于肌动蛋白细胞骨架；胞质溶胶；和纤维中心。用于研究脂肪肝疾病。与人类 ACACA（乙酰辅酶 A 羧化酶 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Acetyl-CoA Carboxylase activity; biotin binding activity; and kinase binding activity. Involved in fatty acid biosynthetic process; response to organic cyclic compound; and response to xenobiotic stimulus. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Used to study fatty liver disease. Orthologous to human ACACA (Acetyl-CoA Carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Acaca 基因产物(1)

mRNA Protein Name
NM_022193.2 NP_071529.2 acetyl-CoA carboxylase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetyl-CoA carboxylase activity IDA
IDA: 通过直接分析推断
11735100 RGD
enables biotin binding IDA
IDA: 通过直接分析推断
12949377 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
11735100 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
26394137 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25943649 RGD
involved in response to organic cyclic compound IMP
IMP: 通过突变表型推断
12842871 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16979414 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acaca 蛋白结构

AccC

AccC: COG0439 (155 - 657)

AccB

AccB: cl33922 (708 - 855)

Biotin_lipoyl

Biotin_lipoyl: pfam00364 (790 - 855)

ACC_central

ACC_central: pfam08326 (857 - 1606)

Carboxyl_trans

Carboxyl_trans: pfam01039 (1706 - 2254)

  • 0
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  • 800
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  • 2000
  • 2384 a.a.
蛋白主名 其他名称

acetyl-CoA carboxylase 1

ACC-alpha

acetyl-coenzyme A carboxylase alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00119 ACACA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00120 Acaca Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00121 Acaca Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acaca NCBI NCBI:31
Macaca fascicularis Acaca NCBI NCBI:102138812
Macaca mulatta Acaca NCBI NCBI:714218
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