2. Gene
  3. RPS6KB2 - ribosomal protein S6 kinase B2 Gene

RPS6KB2 - ribosomal protein S6 kinase B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 B2

种属: Homo sapiens

同用名: KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta

基因 ID: 6199 | 基因类型: protein coding

关于 RPS6KB2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,428,494-67,435,401 (from NCBI)

This gene has 12 transcripts (splice variants), 199 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 31.3), esophagus (RPKM 20.5) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含激酶催化结构域并磷酸化 S6 核糖体蛋白和真核翻译起始因子 4B (eIF4B) 。 S6 的磷酸化导致蛋白质合成和细胞增殖的增加。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

RPS6KB2 基因产物(5)

mRNA Protein Name
XM_006718656.4 XP_006718719.1 ribosomal protein S6 kinase beta-2 isoform X2
XM_047427395.1 XP_047283351.1 ribosomal protein S6 kinase beta-2 isoform X1
NM_003952.3 NP_003943.2 ribosomal protein S6 kinase beta-2
XM_047427396.1 XP_047283352.1 ribosomal protein S6 kinase beta-2 isoform X3
NM_001007071.1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
29750193 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in TOR signaling IMP
IMP: 通过突变表型推断
29750193 GOA
involved in positive regulation of translational initiation IDA
IDA: 通过直接分析推断
29750193 GOA
involved in positive regulation of translational initiation IMP
IMP: 通过突变表型推断
16763566 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KB2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (67 - 328)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (349 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase beta-2

70 kDa ribosomal protein S6 kinase 2

P70S6K2

S6 kinase-related kinase

S6K-beta

S6K-beta-2

p70 S6 kinase beta

p70 S6K-beta

p70 S6KB

p70 ribosomal S6 kinase beta

p70-S6K 2

ribosomal protein S6 kinase, 70kDa, polypeptide 2

serine/threonine-protein kinase 14 beta

serine/threonine-protein kinase 14B

RPS6KB2 抗体

目录号 产品名 应用 反应物种
HY-P81769 S6K2 Antibody (YA1514) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82145 Phospho-S6K2 (Ser371) Antibody (YA1890) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome
Spotted Fever

Spotted Fevers

Spotted Fever Group Rickettsial Disease

Tick-Borne Rickettsioses

Tick-Borne Typhus Nos

Rocky Mountain Spotted Fever

Sao Paulo Fever

Sao Paulo Typhus

Lone Star Spotted Fever

Colombian Spotted Fever

American Spotted Fever

Tick Typhus Due To Rickettsia Rickettsii

Rocky Mountain Tick Fever

Boutonneuse Fever

Mediterranean Tick Fever

Fièvre Boutonneuse

Mediterranean Spotted Fever

Tick Typhus Due To Rickettsia Conorii

African Tick Typhus

Indian Tick Typhus

Kenya Tick Typhus

North Asian Tick Fever

Siberian Tick Typhus

Tick Typhus Due To Rickettsia Siberica

North Asian Spotted Fever

Queensland Tick Typhus

Queensland Fever
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12265 RPS6KB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12266 Rps6kb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12267 Rps6kb2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RPS6KB2 VGNC VGNC:76934
Canis familiaris RPS6KB2 VGNC VGNC:45745
Bos taurus RPS6KB2 VGNC VGNC:34147
Mus musculus RPS6KB2 MGD MGI:1927343
Rattus norvegicus RPS6KB2 RGD RGD:1305144
Felis catus RPS6KB2 VGNC VGNC:64760
Others RPS6KB2 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z