MAPK12 - mitogen-activated protein kinase 12 Gene

中文名称：丝裂原活化蛋白激酶 12

种属: Homo sapiens

同用名: ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA

基因 ID: 6300 | 基因类型: protein coding

关于 MAPK12

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,252,901-50,261,683 (from NCBI)

This gene has 11 transcripts (splice variants), 288 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues.

功能概要

有丝分裂原活化蛋白激酶家族成员的激活是细胞外信号转导的主要机制。应激激活蛋白激酶是 MAP 激酶的一个亚类。由该基因编码的蛋白质在成肌细胞向肌管分化过程中起着信号转导的作用。[RefSeq 提供，2008 年 7 月]

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

MAPK12 基因产物(2)

mRNA	Protein	Name
NM_002969.6	NP_002960.2	mitogen-activated protein kinase 12 isoform 1
NM_001303252.3	NP_001290181.1	mitogen-activated protein kinase 12 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables magnesium ion binding	IDA IDA: 通过直接分析推断	10508788	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12761180	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	8633070	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in myoblast differentiation	IDA IDA: 通过直接分析推断	8633070	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	15850461	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK12 蛋白结构

Pkinase

0
100
200
300
367 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase 12

MAP kinase 12	MAP kinase p38 gamma
extracellular signal-regulated kinase 6	mitogen-activated protein kinase 3
mitogen-activated protein kinase p38 gamma	stress-activated protein kinase 3

MAPK12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAPK12	P53778	DLG1	Homo sapiens	Q12959	PLA	25241761
种属内	MAPK12	P53778	PKN1	Homo sapiens	Q16512	Anti Tag CoIP	12761180
种属内	MAPK12	P53778	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAPK12 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76532	p38 gamma/MAPK12 Protein, Human (sf9)	P53778-1 (N-G&P, M1-L367)	≥95%
HY-P76533	p38 gamma/MAPK12 Protein, Human (sf9, His-GST)	P53778-1 (M1-L367)	≥95%

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	纯度	是否罕见病
HY-RS08101	MAPK12 Human Pre-designed siRNA Set A	/	否
HY-RS08102	Mapk12 Mouse Pre-designed siRNA Set A	/	否
HY-RS08103	Mapk12 Rat Pre-designed siRNA Set A	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MAPK12	RGD	RGD:70975
Macaca mulatta	MAPK12	VGNC	VGNC:74643
Mus musculus	MAPK12	MGD	MGI:1353438
Bos taurus	MAPK12	VGNC	VGNC:31215
Canis familiaris	MAPK12	VGNC	VGNC:42993
Others	MAPK12	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAPK12 - mitogen-activated protein kinase 12 Gene

关于 MAPK12

功能概要

MAPK12 基因产物(2)

MAPK12 蛋白结构

MAPK12 蛋白互作信息

重组 MAPK12 蛋白

关联疾病

直系同源

热门区域

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MAPK12 - mitogen-activated protein kinase 12 Gene

关于 MAPK12

功能概要

MAPK12 基因产物(2)

MAPK12 蛋白结构

MAPK12 蛋白互作信息

重组 MAPK12 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z