1. Gene
  2. CCL16 - C-C motif chemokine ligand 16 Gene

CCL16 - C-C motif chemokine ligand 16 Gene

中文名称:CC 基序趋化因子配体 16

种属: Homo sapiens

同用名: LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16

基因 ID: 6360 | 基因类型: protein coding

关于 CCL16

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,976,499-35,981,497 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 91 orthologues and 25 paralogues. Biased expression in liver (RPKM 21.1) and spleen (RPKM 0.6).

功能概要

该基因是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一。细胞因子是一个参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的细胞因子对淋巴细胞和单核细胞显示趋化活性,但对中性粒细胞不显示。这种细胞因子还显示出强大的骨髓抑制活性并抑制骨髓祖细胞的增殖。该基因的表达被 IL-10 上调。[RefSeq 提供,2008 年 7 月]

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

CCL16 基因产物(1)

mRNA Protein Name
NM_004590.4 NP_004581.1 C-C motif chemokine 16 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemoattractant activity IDA
IDA: 通过直接分析推断
15001559 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28381538 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCL16 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (33 - 89)

  • 0
  • 100
  • 120 a.a.
蛋白主名 其他名称

C-C motif chemokine 16

IL-10-inducible chemokine

CCL16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCL16 O15467 CCL5 Homo sapiens P13501
SPR
28381538
种属内
CCL16 O15467 CCL5 Homo sapiens P13501
Filter Binding
28381538
种属内
CCL16 O15467 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
CCL16 O15467 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
CCL16 O15467 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL16 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7196 HCC-4/CCL16 Protein, Human (CHO) O15467 (Q24-Q120) ≥95%
HY-P7197 HCC-4/CCL16 Protein, Human O15467 (Q24-Q120) ≥95%

关联疾病

疾病名称 别名
Ring Dermoid Of Cornea

RDC

Ring Dermoid Syndrome

Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

Dermoid Of Cornea, Ring

Cataract 18

Cataract, Autosomal Recessive Congenital 2

Catc2

CTRCT18

Autosomal Recessive Congenital Cataract 2

Cataract 18, Autosomal Recessive

Cataract 18 Autosomal Recessive

Cataract, Type 18

Leber Congenital Amaurosis 1

LCA1

Amaurosis Congenita Of Leber I

Lca

Retinal Blindness, Congenital

Crb

Leber Congenital Amaurosis Type I

Leber Congenital Amaurosis, Type 1

Amaurosis Congenita Of Leber, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma