2. Gene
  3. SNX16 - sorting nexin 16 Gene

SNX16 - sorting nexin 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：排序 nexin 16

种属: Homo sapiens

基因 ID: 64089 | 基因类型: protein coding

关于 SNX16

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,799,583-81,842,185 (from NCBI)

This gene has 11 transcripts (splice variants), 237 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 6.1), esophagus (RPKM 5.5) and 24 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。该基因编码的蛋白质与晚期内体膜相关，参与小管形成、胆固醇转运和四跨膜蛋白 CD81 的转运。编码的蛋白质还抑制细胞迁移和肿瘤发生。[RefSeq 提供，2017 年 1 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, Cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]

SNX16 基因产物(4)

mRNA Protein Name
NM_001348189.2 NP_001335118.1 sorting nexin-16 isoform c
NM_022133.4 NP_071416.2 sorting nexin-16 isoform a
NM_152836.3 NP_690049.1 sorting nexin-16 isoform a
NM_152837.3 NP_690050.1 sorting nexin-16 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12813048 GOA
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
12813048 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
12813048 GOA
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
12813048 GOA
involved in protein targeting to lysosome IMP
IMP: 通过突变表型推断
12813048 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
12813048 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
12813048 GOA
located in late endosome IDA
IDA: 通过直接分析推断
12813048 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX16 蛋白结构

PX

PX: PX domain (118 - 211)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

sorting nexin-16

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 15

SCA15

Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia Type 16

Sca16

Spinocerebellar Ataxia Type 15/16

Spinocerebellar Ataxia 16, Formerly

Sca16, Formerly

Spinocerebellar Ataxia 16

Sca15/16

Ataxia, Spinocerebellar, Type 15
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13529 SNX16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SNX16 MGD MGI:1921968
Rattus norvegicus SNX16 RGD RGD:620295
Bos taurus SNX16 VGNC VGNC:35096
Canis familiaris SNX16 VGNC VGNC:46625
Macaca mulatta SNX16 VGNC VGNC:77710
Felis catus SNX16 VGNC VGNC:65546
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z