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  2. Pi4ka - phosphatidylinositol 4-kinase alpha Gene

Pi4ka - phosphatidylinositol 4-kinase alpha Gene

中文名称:磷脂酰肌醇 4-激酶 α

种属: Rattus norvegicus

同用名: Pik4ca

基因 ID: 64161 | 基因类型: protein coding

关于 Pi4ka

Primary_assembly 11: 83,609,069-83,724,080 forward strand.mRatBN7.2:CM026984.1

This gene has 1 transcript (splice variant), 210 orthologues, 9 paralogues and is associated with 18 phenotypes. Biased expression in Brain (RPKM 24.2), Kidney (RPKM 119.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇 4-激酶活性。预计参与多个过程,包括磷脂酰肌醇磷酸盐生物合成过程;磷脂酰肌醇介导的信号;和病毒复制复合物的形成和维持。预测作用于磷酸化上游或内部。位于高尔基相关囊泡膜。与人 PI4KA(磷脂酰肌醇 4-激酶 α)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; and viral replication complex formation and maintenance. Predicted to act upstream of or within phosphorylation. Located in Golgi-associated vesicle membrane. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pi4ka 基因产物(1)

mRNA Protein Name
NM_022301.2 NP_071637.2 phosphatidylinositol 4-kinase alpha
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: 通过直接分析推断
8662589 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi-associated vesicle membrane IDA
IDA: 通过直接分析推断
8662589 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Pi4ka 蛋白结构

PI4K_N

PI4K_N: cl44709 (389 - 1525)

PI4Ka

PI4Ka: cd00871 (1558 - 1733)

PI4Kc_III_alpha

PI4Kc_III_alpha: cd05167 (1794 - 2112)

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  • 2114 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-kinase alpha

PI4-kinase alpha

PI4K-alpha

leuserpin 2

phosphatidylinositol 4-kinase a

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

ptdIns-4-kinase alpha

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pi4ka NCBI NCBI:5297