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  2. Casp2 - caspase 2 Gene

Casp2 - caspase 2 Gene

中文名称:半胱天冬酶 2

种属: Rattus norvegicus

基因 ID: 64314 | 基因类型: protein coding

关于 Casp2

Primary_assembly 4: 71,149,669-71,167,379 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 215 orthologues, 12 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 234.6), Spleen (RPKM 136.1) and 9 other tissues.

功能概要

预测该基因编码的蛋白可使半胱氨酸型内肽酶活性参与细胞凋亡过程;相同的蛋白质结合活性;和蛋白质结构域特异性结合活性。涉及多个过程,包括老化;动物器官发育;和神经元凋亡过程的正调控。位于膜和线粒体中。癫痫持续状态的生物标志物。与人类 CASP2(caspase 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable cysteine-type endopeptidase activity involved in apoptotic process; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including aging; animal organ development; and positive regulation of neuron apoptotic process. Located in membrane and mitochondrion. Biomarker of status epilepticus. Orthologous to human CASP2 (Caspase 2). [provided by Alliance of Genome Resources, Apr 2022]

Casp2 基因产物(1)

mRNA Protein Name
NM_022522.3 NP_071967.2 caspase-2

Casp2 蛋白结构

CARD_CASP2

CARD_CASP2: cd08332 (31 - 117)

CASc

CASc: smart00115 (191 - 464)

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  • 470 a.a.
蛋白主名 其他名称

caspase-2

CASP-2

ICH-1 protease

protease ICH-1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casp2 NCBI NCBI:835