2. Gene
  3. BLVRA - biliverdin reductase A Gene

BLVRA - biliverdin reductase A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胆绿素还原酶 A

种属: Homo sapiens

同用名: BVR; BLVR; BVRA

基因 ID: 644 | 基因类型: protein coding

关于 BLVRA

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:43,758,122-43,807,342 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 33.2), lung (RPKM 23.1) and 25 other tissues.

功能概要

该基因编码的蛋白质属于胆绿素还原酶家族，其成员在 NADPH 或 NADH 存在的情况下催化胆绿素转化为胆红素。该基因的突变与高胆绿素血症有关。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

BLVRA 基因产物(2)

mRNA Protein Name
NM_000712.4 NP_000703.2 biliverdin reductase A
NM_001253823.2 NP_001240752.1 biliverdin reductase A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables biliberdin reductase (NAD+) activity IDA
IDA: 通过直接分析推断
7929092 GOA
enables biliverdin reductase [NAD(P)+] activity IDA
IDA: 通过直接分析推断
7929092 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18463290 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heme catabolic process IDA
IDA: 通过直接分析推断
10858451 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
7929092 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BLVRA 蛋白结构

GFO_IDH_MocA

GFO_IDH_MocA: Oxidoreductase family, NAD-binding Rossmann fold (9 - 124)

Biliv-reduc_cat

Biliv-reduc_cat: Biliverdin reductase, catalytic (132 - 245)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

biliverdin reductase A

BVR A

重组 BLVRA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7664 Biliverdin Reductase A/BLVRA Protein, Human (C-His) P53004 (E6-S294) ≥95%

关联疾病

疾病名称 别名
Hyperbiliverdinemia

Green Jaundice

HBLVD
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Pneumothorax

Pneumothorax Nos

Air Leak Nos

Pleural Air Leak Nos
Kernicterus

Bilirubin Encephalopathy

Hyperbilirubinemic Encephalopathy

Kernicterus Spectrum Disorder
Gilbert Syndrome

Gilbert Disease

Gilbert'S Disease

Gilbert'S Syndrome

Cholemia, Familial

Familial Nonhemolytic Jaundice

Meulengracht Syndrome

Gilbert Syndrome, Susceptibility To

Hyperbilirubinemia, Gilbert Type

Hblrg

Hyperbilirubinemia, Arias Type

Hyperbilirubinemia I

Constitutional Hyperbilirubinemia

Gilbert-Meulengracht Syndrome

Hereditary Nonhemolytic Jaundice

Hyperbilirubinemia Arias Type

Hyperbilirubinemia Type 1

Constitutional Liver Dysfunction

Gilbert-Lereboullet Syndrome

Hyperbilirubinemia 1

Unconjugated Benign Bilirubinemia

GILBS

Gilberts Syndrome

Familial Nonhaemolytic Jaundice

Constitutional Hyperbilirubinaemia

Hereditary Nonhaemolytic Bilirubinaemia

Familial Nonhaemolytic Bilirubinaemia

Idiopathic Hyperbilirubinaemia

Icterus Intermittens Juvenilis

Chronic Intermittent Juvenile Jaundice

Low-Grade Chronic Hyperbilirubinaemia Syndrome

Benign Unconjugated Bilirubinaemia Syndrome

Hereditary Nonhaemolytic Jaundice

Idiopathic Unconjugated Hyperbilirubinaemia

Gilbert--Lereboullet Syndrome

Constitutional Hepatic Dysfunction

Meulengracht Icterus

Cholaemia Familiaris Simplex

Familial Cholaemia

Congenital Familial Cholaemia

Physiologic Cholaemia

Hyperbilirubinaemia Type 1

Gilbert Cholaemia
Acute Contagious Conjunctivitis

Pink Eye

Contagious Opthalmia

Pinkeye

Conjunctivitis

Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Acute Conjunctivitis
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome

Crigler-Najjar Syndrome Type 1

Bilirubin Udp Glucuronyl Transferase Deficiency

Crigler Najjar Syndrome

Crigler Najjar Syndrome, Type 1

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

Bilirubin-Ugt Deficiency

Hyperbilirubinemia, Crigler-Najjar Type I

Hblrcn1

Familial Nonhemolytic Unconjugated Hyperbilirubinemia

Hereditary Unconjugated Hyperbilirubinemia

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

Bilirubin-Ugt Deficiency Type 1

Crigler-Najjar Syndrome 1

CN1

Cn-I

Crigler-Najjar Syndrome Type I

Hereditary Unconjugated Hyperbilirubinaemia

Ugt Deficiency

Bilirubin Glucuronosyltransferase Deficiency

Crigler-Najjar Disease Or Syndrome

Deficiency Of Glucuronosyltransferase

Glucuronyl Transferase Deficiency

Glucuronyltransferase Deficiency

Udp Glucuronyl Transferase Deficiency

Cns - [Crigler-Najjar Syndrome]

Congenital Familial Nonhemolytic Jaundice
Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Saccular Cerebral Aneurysm

Aneurysm, Intracranial Berry

Aneurysmal Subarachnoid Hemorrhage

Aneurysm, Intracranial Berry, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01526 BLVRA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BLVRA RGD RGD:620721
Canis familiaris BLVRA VGNC VGNC:38471
Macaca mulatta BLVRA VGNC VGNC:70256
Bos taurus BLVRA VGNC VGNC:26510
Mus musculus BLVRA MGD MGI:88170
Others BLVRA NCBI
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