2. Gene
  3. BLVRB - biliverdin reductase B Gene

BLVRB - biliverdin reductase B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胆绿素还原酶 B

种属: Homo sapiens

同用名: FLR; BVRB; SDR43U1; HEL-S-10

基因 ID: 645 | 基因类型: protein coding

关于 BLVRB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,447,768-40,465,745 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues.

功能概要

哺乳动物血红素代谢的最后一步是由胞质胆绿素还原酶 A 和 B (EC 1.3.1.24) 催化的。[OMIM 提供，2009 年 7 月]

The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase Enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

BLVRB 基因产物(1)

mRNA Protein Name
NM_000713.3 NP_000704.1 flavin reductase (NADPH)
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables biliverdin reductase [NAD(P)+] activity IDA
IDA: 通过直接分析推断
7929092 GOA
enables peptidyl-cysteine S-nitrosylase activity IDA
IDA: 通过直接分析推断
38056462 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables riboflavin reductase (NADPH) activity IDA
IDA: 通过直接分析推断
11224564 GOA
enables riboflavin reductase (NADPH) activity IMP
IMP: 通过突变表型推断
27207795 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heme catabolic process IDA
IDA: 通过直接分析推断
7929092 GOA
involved in megakaryocyte differentiation IMP
IMP: 通过突变表型推断
27207795 GOA
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
38056462 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
38056462 GOA
located in cytosol IDA
IDA: 通过直接分析推断
7929092 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BLVRB 蛋白结构

NAD_binding_10

NAD_binding_10: NAD(P)H-binding (6 - 190)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

flavin reductase (NADPH)

BVR-B

重组 BLVRB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76172 BLVRB Protein, Human (His) P30043 (A2-Q206) ≥95%

关联疾病

疾病名称 别名
Pyloric Stenosis
Achalasia

Cardiospasm

Achalasia Of Cardia

Esophageal Achalasia

Hypertensive Lower Esophageal Sphincter

Idiopathic Achalasia

Achalasia Cardia

Idiopathic Achalasia Of Esophagus

Primary Achalasia

Achalasia Of Esophagus

Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

Aperistalsis Of The Oesophagus

Achalasia Of Oesophagus

Oesophageal Achalasia

Achalasia Nos

Cardia Spasm

Cardia Achalasia

Oesophageal Cardiospasm

Oesophagus Achalasia

Reflex Cardiospasm
Methemoglobinemia
Intestinal Atresia
Obstructive Jaundice

Jaundice, Obstructive

Cholestatic Jaundice

Cholestatic Jaundice Syndrome

Obstructive Hyperbilirubinemia

Jaundice Obstructive

Jaundice Cholestatic
Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis
Megacolon

Dilatation Of Colon
Pulpitis

Pulp Stones

Pulpitis Nos
Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome
Scrapie
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01527 BLVRB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BLVRB RGD RGD:1306080
Mus musculus BLVRB MGD MGI:2385271
Macaca mulatta BLVRB VGNC VGNC:70257
Felis catus BLVRB VGNC VGNC:60126
Canis familiaris BLVRB VGNC VGNC:38472
Bos taurus BLVRB VGNC VGNC:26511
Others BLVRB NCBI
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