2. Gene
  3. CPEB1 - cytoplasmic polyadenylation element binding protein 1 Gene

CPEB1 - cytoplasmic polyadenylation element binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞质聚腺苷酸化元件结合蛋白 1

种属: Homo sapiens

同用名: CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1

基因 ID: 64506 | 基因类型: protein coding

关于 CPEB1

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,543,201-82,648,795 (from NCBI)

This gene has 19 transcripts (splice variants), 1 gene allele, 233 orthologues and 3 paralogues. Biased expression in testis (RPKM 19.2), brain (RPKM 6.3) and 8 other tissues.

功能概要

该基因编码细胞质聚腺苷酸化元件结合蛋白家族的成员。这种高度保守的蛋白质与特定的 RNA 序列结合，称为细胞质聚腺苷酸化元件，存在于某些 mRNA 的 3' 非翻译区。编码的蛋白质在细胞质和细胞核中发挥作用。它参与 mRNA 翻译的调节，以及 3' 非翻译区的加工，并可能在细胞增殖和肿瘤发生中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

CPEB1 基因产物(35)

mRNA Protein Name
NM_001079533.2 NP_001073001.1 cytoplasmic polyadenylation element-binding protein 1 isoform 2
NM_001079534.2 NP_001073002.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001079535.2 NP_001073003.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001288819.2 NP_001275748.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001288820.2 NP_001275749.1 cytoplasmic polyadenylation element-binding protein 1 isoform 4
NM_001365240.1 NP_001352169.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001365241.1 NP_001352170.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001365242.1 NP_001352171.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001365243.1 NP_001352172.1 cytoplasmic polyadenylation element-binding protein 1 isoform 6
NM_001365244.1 NP_001352173.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365245.1 NP_001352174.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365246.1 NP_001352175.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365247.1 NP_001352176.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365248.1 NP_001352177.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365249.1 NP_001352178.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001365250.1 NP_001352179.1 cytoplasmic polyadenylation element-binding protein 1 isoform 2
NM_001387061.1 NP_001373990.1 cytoplasmic polyadenylation element-binding protein 1 isoform 7
NM_001387062.1 NP_001373991.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387063.1 NP_001373992.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387064.1 NP_001373993.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387065.1 NP_001373994.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387066.1 NP_001373995.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387067.1 NP_001373996.1 cytoplasmic polyadenylation element-binding protein 1 isoform 5
NM_001387068.1 NP_001373997.1 cytoplasmic polyadenylation element-binding protein 1 isoform 2
NM_001387069.1 NP_001373998.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387070.1 NP_001373999.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387071.1 NP_001374000.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387072.1 NP_001374001.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387073.1 NP_001374002.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387074.1 NP_001374003.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387075.1 NP_001374004.1 cytoplasmic polyadenylation element-binding protein 1 isoform 3
NM_001387076.1 NP_001374005.1 cytoplasmic polyadenylation element-binding protein 1 isoform 8
NM_001387077.1 NP_001374006.1 cytoplasmic polyadenylation element-binding protein 1 isoform 4
NM_001387078.1 NP_001374007.1 cytoplasmic polyadenylation element-binding protein 1 isoform 4
NM_030594.5 NP_085097.3 cytoplasmic polyadenylation element-binding protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28383716 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
18752464 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
18752464 GOA
involved in negative regulation of cytoplasmic translation IMP
IMP: 通过突变表型推断
18752464 GOA
involved in regulation of mRNA 3'-end processing IDA
IDA: 通过直接分析推断
28383716 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28383716 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytoplasmic polyadenylation element-binding protein 1

CPE-binding protein 1

CPEB1 抗体

目录号 产品名 应用 反应物种
HY-P82612 CPEB1 Antibody (YA2357) WB, IP Human

关联疾病

疾病名称 别名
Non-Gestational Ovarian Choriocarcinoma
Choriocarcinoma Of Ovary

Ovarian Choriocarcinoma
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145944 ASR-488 Inducer 99.73% 否
HY-RS03091 CPEB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CPEB1 VGNC VGNC:104382
Bos taurus CPEB1 VGNC VGNC:103719
Mus musculus CPEB1 MGD MGI:108442
Rattus norvegicus CPEB1 RGD RGD:1310421
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