2. Gene
  3. ANAPC1 - anaphase promoting complex subunit 1 Gene

ANAPC1 - anaphase promoting complex subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：后期促进复合亚基 1

种属: Homo sapiens

同用名: APC1; MCPR; TSG24

基因 ID: 64682 | 基因类型: protein coding

关于 ANAPC1

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,766,231-111,884,193 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 6.5) and 25 other tissues.

功能概要

该基因编码后期促进复合物的一个亚基。该复合物是一种 E3 泛素连接酶，通过泛素化以降解为目标的蛋白质来调节细胞周期从中期到后期的进程。[RefSeq 提供，2011 年 12 月]

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin Ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

ANAPC1 基因产物(1)

mRNA Protein Name
NM_022662.4 NP_073153.1 anaphase-promoting complex subunit 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
29033132 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of anaphase-promoting complex IDA
IDA: 通过直接分析推断
16364912 GOA
part of anaphase-promoting complex IPI
IPI: 通过物理相互作用推断
27120157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANAPC1 蛋白结构

ANAPC1

ANAPC1: Anaphase-promoting complex subunit 1 (149 - 227)

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  • 1800
  • 1944 a.a.
蛋白主名 其他名称

anaphase-promoting complex subunit 1

anaphase-promoting complex 1 (meiotic checkpoint regulator)

关联疾病

疾病名称 别名
Rothmund-Thomson Syndrome, Type 1

RTS1

Poikiloderma Atrophicans And Cataract

Rothmund-Thomson Syndrome Type 1

Poikiloderma Of Rothmund-Thomson Type 1

Rothmund-Thomson Syndrome 1
Rothmund-Thomson Syndrome, Type 2

Rothmund-Thomson Syndrome

Rts

RTS2

Poikiloderma Of Rothmund-Thomson

Rothmund-Thomson Syndrome Type 2

Congenital Poikiloderma

Poikiloderma Congenitale

Poikiloderma Atrophicans And Cataract

Poikiloderma Congenitale Of Rothmund-Thomson

Poikiloderma Of Rothmund-Thomson Type 2

Rothmund-Thomson Syndrome 2

Erythrokeratodermia Variabilis
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00677 ANAPC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ANAPC1 MGD MGI:103097
Bos taurus ANAPC1 VGNC VGNC:25879
Canis familiaris ANAPC1 VGNC VGNC:37844
Rattus norvegicus ANAPC1 RGD RGD:1306629
Felis catus ANAPC1 VGNC VGNC:59774
Macaca mulatta ANAPC1 VGNC VGNC:69640
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