2. Gene
  3. ST3GAL1 - ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Gene

ST3GAL1 - ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST3 β-半乳糖苷 α-2,3-唾液酸转移酶 1

种属: Homo sapiens

同用名: ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1

基因 ID: 6482 | 基因类型: protein coding

关于 ST3GAL1

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,454,848-133,571,887 (from NCBI)

This gene has 16 transcripts (splice variants), 437 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues.

功能概要

该基因编码的蛋白质是一种 II 型膜蛋白，可催化唾液酸从 CMP-唾液酸转移到含半乳糖的底物。编码的蛋白质通常存在于高尔基体中，但可以通过蛋白水解加工成可溶性形式。编码蛋白质的正确糖基化可能对其唾液酸转移酶活性至关重要。这种蛋白质是糖基转移酶家族 29 的成员，可以使用与唾液酸转移酶 4B 相同的受体底物。已发现该基因编码相同蛋白质的两个转录变体。可能存在其他转录变体，但尚未完全表征。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its Sialyltransferase activity. This protein, which is a member of Glycosyltransferase family 29, can use the same acceptor substrates as does Sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

ST3GAL1 基因产物(2)

mRNA Protein Name
NM_003033.4 NP_003024.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_173344.3 NP_775479.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
IDA: 通过直接分析推断
8027041 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ganglioside biosynthetic process via lactosylceramide IDA
IDA: 通过直接分析推断
8027041 GOA
involved in protein sialylation IDA
IDA: 通过直接分析推断
8027041 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi medial cisterna membrane IDA
IDA: 通过直接分析推断
9182658 GOA
located in Golgi trans cisterna membrane IDA
IDA: 通过直接分析推断
9182658 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
9182658 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST3GAL1 蛋白结构

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (80 - 339)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
蛋白主名 其他名称

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase

关联疾病

疾病名称 别名
Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-E70298 ST3 β-Gal α-2,3-Sialyltransferase 1 / 否
HY-RS13846 ST3GAL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ST3GAL1 VGNC VGNC:46850
Macaca mulatta ST3GAL1 VGNC VGNC:77825
Rattus norvegicus ST3GAL1 RGD RGD:1309373
Bos taurus ST3GAL1 VGNC VGNC:35331
Mus musculus ST3GAL1 MGD MGI:98304
Felis catus ST3GAL1 VGNC VGNC:65719
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z