2. Gene
  3. ST3GAL2 - ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Gene

ST3GAL2 - ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST3 β-半乳糖苷 α-2,3-唾液酸转移酶 2

种属: Homo sapiens

同用名: SIAT4B; ST3GALII; Gal-NAc6S; ST3GalA.2

基因 ID: 6483 | 基因类型: protein coding

关于 ST3GAL2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,375,977-70,439,100 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 6.9), spleen (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种 II 型膜蛋白，可催化唾液酸从 CMP-唾液酸转移到含半乳糖的底物。编码的蛋白质通常存在于高尔基体中，但可以通过蛋白水解加工成可溶性形式。这种蛋白质是糖基转移酶家族 29 的成员，可以使用与唾液酸转移酶 4A 相同的受体底物。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of Glycosyltransferase family 29, can use the same acceptor substrates as does Sialyltransferase 4A. [provided by RefSeq, Jul 2008]

ST3GAL2 基因产物(1)

mRNA Protein Name
NM_006927.4 NP_008858.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
IDA: 通过直接分析推断
9266697 GOA
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
IDA: 通过直接分析推断
8920913 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
25916169 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ganglioside biosynthetic process via lactosylceramide IDA
IDA: 通过直接分析推断
8920913 GOA
involved in globoside biosynthetic process via lactosylceramide IDA
IDA: 通过直接分析推断
12716912 GOA
involved in glycolipid biosynthetic process IDA
IDA: 通过直接分析推断
9266697 GOA
involved in glycoprotein biosynthetic process IDA
IDA: 通过直接分析推断
9266697 GOA
involved in lipid glycosylation IDA
IDA: 通过直接分析推断
9266697 GOA
involved in oligosaccharide biosynthetic process IDA
IDA: 通过直接分析推断
9266697 GOA
involved in protein glycosylation IDA
IDA: 通过直接分析推断
9266697 GOA
involved in protein sialylation IDA
IDA: 通过直接分析推断
9266697 GOA
involved in sialylation IDA
IDA: 通过直接分析推断
9266697 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
25916169 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST3GAL2 蛋白结构

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (91 - 349)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase

关联疾病

疾病名称 别名
Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney
Salt And Pepper Syndrome

Salt & Pepper Syndrome

Salt-And-Pepper Syndrome
West Syndrome

Infantile Spasms

Infantile Spasms Syndrome

Infantile Spasm

X-Linked Infantile Spasm Syndrome

X-Linked Infantile Spasms

Epileptic Encephalopathy, Early Infantile, 1

Is

Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg

West'S Syndrome

Spasms, Infantile

Is -[Infantile Spasm]

Salaam Spasm

Salaam Tic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13847 ST3GAL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ST3GAL2 VGNC VGNC:77826
Mus musculus ST3GAL2 MGD MGI:99427
Rattus norvegicus ST3GAL2 RGD RGD:68413
Felis catus ST3GAL2 VGNC VGNC:65720
Bos taurus ST3GAL2 VGNC VGNC:35332
Canis familiaris ST3GAL2 VGNC VGNC:46851
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