SLC26A6 - solute carrier family 26 member 6 Gene

中文名称：溶质载体家族 26 成员 6

种属: Homo sapiens

基因 ID: 65010 | 基因类型: protein coding

关于 SLC26A6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,625,723-48,635,461 (from NCBI)

This gene has 22 transcripts (splice variants), 354 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 11.7), bone marrow (RPKM 8.2) and 25 other tissues.

功能概要

该基因属于溶质载体 26 家族，其成员编码阴离子转运蛋白。这个特殊的家族成员编码一种参与运输氯化物、草酸盐、硫酸盐和碳酸氢盐的蛋白质。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2013 年 8 月]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

SLC26A6 基因产物(6)

mRNA	Protein	Name
NM_001040454.1	NP_001035544.1	solute carrier family 26 member 6 isoform 4
NM_001281732.2	NP_001268661.1	solute carrier family 26 member 6 isoform 5
NM_001281733.2	NP_001268662.1	solute carrier family 26 member 6 isoform 6
NM_022911.3	NP_075062.2	solute carrier family 26 member 6 isoform 1
NM_134263.3	NP_599025.2	solute carrier family 26 member 6 isoform 2
NM_134426.3	NP_602298.2	solute carrier family 26 member 6 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables bicarbonate transmembrane transporter activity	IDA IDA: 通过直接分析推断	12444019	GOA
enables chloride transmembrane transporter activity	IDA IDA: 通过直接分析推断	12444019	GOA
enables chloride:bicarbonate antiporter activity	IDA IDA: 通过直接分析推断	12444019	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12444019	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: 通过直接分析推断	15548529	GOA
enables solute:inorganic anion antiporter activity	IMP IMP: 通过突变表型推断	20501439	GOA
enables sulfate transmembrane transporter activity	IDA IDA: 通过直接分析推断	12444019	GOA
enables sulfate:bicarbonate antiporter activity	IDA IDA: 通过直接分析推断	12444019	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiotensin-activated signaling pathway	IDA IDA: 通过直接分析推断	15990874	GOA
involved in bicarbonate transport	IDA IDA: 通过直接分析推断	15990874	GOA
involved in bicarbonate transport	IMP IMP: 通过突变表型推断	20501439	GOA
involved in cellular response to type II interferon	IDA IDA: 通过直接分析推断	18655181	GOA
involved in chloride transport	IDA IDA: 通过直接分析推断	15990874	GOA
involved in chloride transport	IMP IMP: 通过突变表型推断	20501439	GOA
involved in oxalate transport	IMP IMP: 通过突变表型推断	20501439	GOA
involved in protein kinase C signaling	IDA IDA: 通过直接分析推断	15990874	GOA
involved in regulation of intracellular pH	IDA IDA: 通过直接分析推断	15990874	GOA
involved in regulation of intracellular pH	IMP IMP: 通过突变表型推断	20501439	GOA
involved in sulfate transmembrane transport	IMP IMP: 通过突变表型推断	20501439	GOA
involved in transepithelial chloride transport	IMP IMP: 通过突变表型推断	20501439	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	11087667	GOA
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	11087667	GOA
located in brush border membrane	IDA IDA: 通过直接分析推断	11087667	GOA
located in membrane	IDA IDA: 通过直接分析推断	11087667	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12444019	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC26A6 蛋白结构

Sulfate_transp

STAS

0
200
400
600
759 a.a.

蛋白主名

其他名称

solute carrier family 26 member 6

anion exchange transporter

关联疾病

疾病名称

别名

Urolithiasis

Spermatocele

Sialolithiasis

Sialolith	Stone Of Salivary Gland Or Duct
Salivary Gland Calculi	Salivary Gland Stone
Calculus Of Salivary Gland Or Duct	Calculus Of Salivary Gland
Salivary Calculus	Salivary Gland Calculus
Salivary Stone	Salivary Duct Calculi
Sialodocholithiasis

Renal Tuberculosis

Tuberculosis, Renal	Tuberculosis Of Kidney
Tuberculosis Renal

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Diarrhea 1, Secretory Chloride, Congenital

DIAR1	Chloride Diarrhea, Congenital, Finnish Type
Congenital Secretory Chloride Diarrhea 1	Congenital Chloride Diarrhea Finnish Type
Congenital Chloride Diarrhea	Chloridorrhea, Congenital
Congenital Chloride Diarrhoea Finnish Type	Congenital Chloridorrhea
Congenital Secretory Chloride Diarrhoea 1	Chloridorrhea Congenital
Cld	Diarrhea 1 Secretory Chloride Congenital
Diarrhea, Type 1, Chloride, Secretory, Congenital

Lower Urinary Tract Calculus

Calculus Of Lower Urinary Tract

Motility-Related Diarrhea

Urogenital Tuberculosis

Tuberculosis, Urogenital

Genitourinary Tuberculosis

Bladder Calculus

Urinary Bladder Calculi	Urinary Bladder Stone
Bladder Calculi	Bladder Stone
Urinary Bladder Calculus	Vesical Calculi
Vesical Calculus	Vesicolithiasis
Cystolithiasis	Cystic Calculi
Cystic Calculus

Nephrolithiasis, Calcium Oxalate

Kidney Stones	Calculus Of Kidney
Kidney Calculi	Nephrolithiasis
Renal Calculi	Calcium Oxalate Urolithiasis
CAON	Urolithiasis, Calcium Oxalate
Calcium Oxalate Nephrolithiasis	Kidney Stone
Nephrolith	Renal Calculus
Urinary Stones	Renal Stone
Calculus, Kidney	Calculus, Renal
Renal Lithiasis	Renal Stones
Urolithiasis	Renal Calculus Or Stone
Stone In Kidney	Nephritic Calculus
Multiple Kidney Calculi	Multiple Kidney Calculus
Nephrolithiasis Nos	Pelvic Nephrolithiasis
Pelviolithiasis	Pelvis Nephrolithiasis

Diastrophic Dysplasia

Diastrophic Dwarfism	DTD
Dd	Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant
Dysplasia, Diastrophic	Diastrophic Dysplasia Variant

Hyperoxaluria, Primary, Type Iii

Primary Hyperoxaluria Type 3	HP3
Ph Iii	Primary Hyperoxaluria Type Iii
Hyperoxaluria Primary 3	Hyperoxaluria Non-Hp1/Non-Hp2
Hyperoxaluria Non-Ph I/Ph Ii Form	Hyperoxaluria Primary Type Iii

Inflammatory Diarrhea

Pendred Syndrome

Goiter-Deafness Syndrome	Deafness With Goiter
PDS	Thyroid Dyshormonogenesis 2b
Tdh2b	Autosomal Recessive Sensorineural Hearing Impairment And Goiter
Pendred'S Syndrome	Thyroid Hormonogenesis, Genetic Defect In, 2b
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b	Congenital Hypothyroidism Due To Dyshormonogenesis 2b
Genetic Defect In Thyroid Hormonogenesis 2b	Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter
Goiter-Hearing Loss Syndrome	Goitre-Deafness Syndrome
Goitre Deafness

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-154912	PAT1inh-B01		98.32%	否
HY-159706	S9-A13	Inhibitor	99.68%	否
HY-154912A	PAT1inh-B01 hydrochloride	Inhibitor	≥98.0%	否
HY-162033	PAT1inh-A0030		/	否
HY-RS13140	SLC26A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SLC26A6	VGNC	VGNC:34781
Rattus norvegicus	SLC26A6	RGD	RGD:1310197
Mus musculus	SLC26A6	MGD	MGI:2159728
Macaca mulatta	SLC26A6	VGNC	VGNC:77483

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC26A6 - solute carrier family 26 member 6 Gene

关于 SLC26A6

功能概要

SLC26A6 基因产物(6)

SLC26A6 蛋白结构

关联疾病

直系同源

热门区域

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SLC26A6 - solute carrier family 26 member 6 Gene

关于 SLC26A6

功能概要

SLC26A6 基因产物(6)

SLC26A6 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z