2. Gene
  3. SMARCD3 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Gene

SMARCD3 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：SWI/SNF 相关、基质相关、肌动蛋白依赖性染色质调节因子，d 亚科，成员 3

种属: Homo sapiens

同用名: Rsc6p; BAF60C; CRACD3

基因 ID: 6604 | 基因类型: protein coding

关于 SMARCD3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,238,780-151,277,149 (from NCBI)

This gene has 15 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 23.8), heart (RPKM 18.1) and 23 other tissues.

功能概要

由该基因编码的蛋白质是 SWI/SNF 蛋白质家族的成员，其成员具有解旋酶和 ATP 酶活性，被认为通过改变这些基因周围的染色质结构来调节某些基因的转录。编码的蛋白质是大型 ATP 依赖性染色质重塑复合体 SNF/SWI 的一部分，与酵母 Swp73 蛋白质具有序列相似性。已发现该基因的多个选择性剪接转录变体，但尚未确定某些变体的生物学有效性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

SMARCD3 基因产物(3)

mRNA Protein Name
NM_001003801.2 NP_001003801.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 2
NM_001003802.2 NP_001003802.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1
NM_003078.4 NP_003069.2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
enables nuclear receptor coactivator activity IMP
IMP: 通过突变表型推断
17363140 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
11726552 GOA
involved in neural retina development IEP
IEP: 通过表达模式推断
18816825 GOA
involved in nucleosome disassembly IDA
IDA: 通过直接分析推断
8895581 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14701856 GOA
involved in positive regulation of neuroblast proliferation IDA
IDA: 通过直接分析推断
18816825 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17363140 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF complex IDA
IDA: 通过直接分析推断
8804307 GOA
located in chromatin IDA
IDA: 通过直接分析推断
17363140 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17363140 GOA
part of npBAF complex IDA
IDA: 通过直接分析推断
18816825 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14701856 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMARCD3 蛋白结构

SWIB

SWIB: SWIB/MDM2 domain (260 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
蛋白主名 其他名称

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

60 kDa BRG-1/Brm-associated factor subunit C

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13414 SMARCD3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SMARCD3 RGD RGD:1311869
Bos taurus SMARCD3 VGNC VGNC:34995
Macaca mulatta SMARCD3 VGNC VGNC:77655
Canis familiaris SMARCD3 VGNC VGNC:46539
Felis catus SMARCD3 VGNC VGNC:65473
Mus musculus SMARCD3 MGD MGI:1914243
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