Lrrk2 - leucine-rich repeat kinase 2 Gene

中文名称：富含亮氨酸重复激酶 2

种属: Mus musculus

同用名: Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik

关于 Lrrk2

功能概要

该基因编码的蛋白可启动多种功能，包括 β-连环蛋白破坏复合物结合活性；相同的蛋白质结合活性；和小的 GTPase 结合活性。参与多个过程，包括细胞分解代谢过程的正调节；调节信号转导；和调节囊泡介导的运输。作用于多个过程的上游或内部，包括高尔基组织；组蛋白脱乙酰酶活性的正调节；和蛋白质输入细胞核。位于几种细胞成分中，包括细胞质囊泡；内质网出口位点；和线粒体。 Wnt 信号体和核糖核蛋白复合物的一部分。在谷氨酸能突触和突触前细胞质中活跃。以多种结构表示，包括 autopod；脑;泌尿生殖系统；肢芽;和脊髓。用于研究帕金森病 8. 该基因与克罗恩病有关的人类直向同源基因；帕金森病；帕金森病 8；帕金森症；和癌症。与人类 LRRK2（富含亮氨酸重复激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of cellular catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; positive regulation of histone deacetylase activity; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including autopod; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]