2. Autophagy
  3. LRRK2
  4. (R,R)-LRRK2-IN-7

(R,R)-LRRK2-IN-7 是 LRRK2-IN-7 (HY-152107) 的异构体。LRRK2-IN-7 是一种有效的、选择性的、CNS 渗透性 LRRK2 激酶抑制剂，IC50 为 0.9 nM。LRRK2-IN-7 的选择性是其他激酶、离子通道和 CYP 酶的 1000 倍以上。

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(R,R)-LRRK2-IN-7 Chemical Structure

(R,R)-LRRK2-IN-7 Chemical Structure

CAS No. : 2307277-92-3

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Other Forms of (R,R)-LRRK2-IN-7:

(R,R)-LRRK2-IN-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R,R)-LRRK2-IN-7 is the isomer of LRRK2-IN-7 (HY-152107). LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes.

IC50 & Target

IC50: 0.9 nM (LRRK2 Kinase)[1]
体外研究
(In Vitro)

LRRK2-IN-7 (compound 25) 既是小鼠乳腺癌抗性蛋白 (BCRP) 底物（小鼠/人 BCRP）也是一种有效的人 BCRP 抑制剂（BCRP IC50 = 0.12 μM）[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R,R)-LRRK2-IN-7 相关抗体:
体内研究
(In Vivo)

在一项为期 7 天的大鼠剂量限制毒性研究中，LRRK2-IN-7 (compound 25) 的耐受性高达 100 mg/kg，每天一次（AUCtot = 330 μM·h）[1]。
在大鼠急性（2 小时）PK/PD 研究中，LRRK2-IN-7 (compound 25) 显示大鼠脑纹状体中 LRRK2 pS935 剂量依赖性降低，EC50 = 0.18 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

414.50

Formula

C24H26N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R,R)-LRRK2-IN-7 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-LRRK2-IN-72307277-92-3LRRK2Leucine-rich repeat kinase 2brain-penetrantATP-competitive,Inhibitorinhibitorinhibit

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目录号：
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