Cntnap2 - contactin associated protein-like 2 Gene

种属: Mus musculus

同用名: Caspr2; mKIAA0868; 5430425M22Rik

基因 ID: 66797 | 基因类型: protein coding

关于 Cntnap2

功能概要

Enables PDZ domain binding activity. Involved in several processes, including chemical synaptic transmission; nervous system development; and synapse organization. Acts upstream of or within glutamatergic neuron differentiation; limbic system development; and neuron projection development. Located in several cellular components, including cerebellar granule cell to Purkinje cell synapse; main axon; and presynaptic active zone membrane. Is integral component of membrane. Part of voltage-gated Potassium Channel complex. Is active in dendrite and excitatory synapse. Is expressed in central nervous system and neural retina. Used to study autism spectrum disorder and cortical dysplasia-focal epilepsy syndrome. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cntnap2 基因产物(2)

mRNA	Protein	Name
NM_001004357.2	NP_001004357.2	contactin-associated protein-like 2 isoform a precursor
NM_025771.3	NP_080047.1	contactin-associated protein-like 2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	25977097	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	20962216	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	32675284	MGI
involved in TOR signaling	IMP IMP: 通过突变表型推断	30816216	MGI
involved in action potential initiation	IMP IMP: 通过突变表型推断	31141683	MGI
involved in associative learning	IMP IMP: 通过突变表型推断	26158416	MGI
involved in axonogenesis	IMP IMP: 通过突变表型推断	28370195	MGI
involved in behavioral response to pain	IGI IGI: 通过遗传相互作用推断	31874168	MGI
involved in cell morphogenesis	IMP IMP: 通过突变表型推断	32675284	MGI
involved in cell population proliferation	IMP IMP: 通过突变表型推断	29028946	MGI
involved in central nervous system myelination	IMP IMP: 通过突变表型推断	29300891	MGI
involved in cerebellar Purkinje cell layer morphogenesis	IMP IMP: 通过突变表型推断	32675284	MGI
involved in cerebellum development	IMP IMP: 通过突变表型推断	32675284	MGI
involved in chemical synaptic transmission	IMP IMP: 通过突变表型推断	23074245	MGI
involved in circadian sleep/wake cycle	IMP IMP: 通过突变表型推断	32889171	MGI
involved in clustering of voltage-gated potassium channels	IMP IMP: 通过突变表型推断	12963709	MGI
involved in dendrite arborization	IMP IMP: 通过突变表型推断	23074245	MGI
involved in dendritic spine development	IMP IMP: 通过突变表型推断	23074245	MGI
involved in dendritic spine maintenance	IMP IMP: 通过突变表型推断	31141683	MGI
involved in dendritic spine organization	IMP IMP: 通过突变表型推断	31141683	MGI
involved in embryonic brain development	IMP IMP: 通过突变表型推断	32879327	MGI
involved in excitatory chemical synaptic transmission	IMP IMP: 通过突变表型推断	30679017	MGI
involved in excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	29300891	MGI
involved in excitatory synapse assembly	IMP IMP: 通过突变表型推断	23074245	MGI
involved in fat cell differentiation	IMP IMP: 通过突变表型推断	22752552	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	29429934	MGI
involved in glial cell proliferation	IMP IMP: 通过突变表型推断	27785461	MGI
acts upstream of or within glutamatergic neuron differentiation	IMP IMP: 通过突变表型推断	25918374	MGI
involved in grooming behavior	IMP IMP: 通过突变表型推断	29300891	MGI
involved in in utero embryonic development	IMP IMP: 通过突变表型推断	32879327	MGI
involved in inflammatory response	IGI IGI: 通过遗传相互作用推断	31874168	MGI
involved in inhibitory chemical synaptic transmission	IMP IMP: 通过突变表型推断	26511255	MGI
involved in inhibitory synapse assembly	IMP IMP: 通过突变表型推断	23074245	MGI
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	32675284	MGI
involved in learning	IMP IMP: 通过突变表型推断	26273832	MGI
involved in limbic system development	IEP IEP: 通过表达模式推断	18179895	MGI
involved in locomotor rhythm	IMP IMP: 通过突变表型推断	32889171	MGI
involved in locomotory behavior	IMP IMP: 通过突变表型推断	26273832	MGI
involved in maintenance of synapse structure	IMP IMP: 通过突变表型推断	25951243	MGI
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	28370195	MGI
involved in motor behavior	IMP IMP: 通过突变表型推断	26273832	MGI
involved in multicellular organism growth	IMP IMP: 通过突变表型推断	26273832	MGI
involved in myelination	IGI IGI: 通过遗传相互作用推断	31641127	MGI
involved in negative regulation of neuronal action potential	IMP IMP: 通过突变表型推断	28768803	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	30816216	MGI
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: 通过突变表型推断	28966979	MGI
involved in neural precursor cell proliferation	IMP IMP: 通过突变表型推断	27785461	MGI
involved in neuromuscular junction development, skeletal muscle fiber	IMP IMP: 通过突变表型推断	28370195	MGI
involved in neuromuscular process	IMP IMP: 通过突变表型推断	28370195	MGI
involved in neuromuscular process controlling posture	IMP IMP: 通过突变表型推断	26273832	MGI
acts upstream of or within neuron projection development	IGI IGI: 通过遗传相互作用推断	19458237	MGI
involved in neuron projection morphogenesis	IMP IMP: 通过突变表型推断	25378149	MGI
involved in neuronal action potential	IGI IGI: 通过遗传相互作用推断	31874168	MGI
involved in neuronal action potential	IMP IMP: 通过突变表型推断	29300891	MGI
involved in positive regulation of neuronal action potential	IMP IMP: 通过突变表型推断	28768803	MGI
involved in postsynaptic density organization	IMP IMP: 通过突变表型推断	28370195	MGI
involved in protein localization	IMP IMP: 通过突变表型推断	22752552	MGI
acts upstream of or within protein localization to juxtaparanode region of axon	IMP IMP: 通过突变表型推断	19109503	MGI
involved in protein localization to juxtaparanode region of axon	IMP IMP: 通过突变表型推断	12963709	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: 通过直接分析推断	25918374	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: 通过突变表型推断	25918374	MGI
involved in response to dietary excess	IMP IMP: 通过突变表型推断	22752552	MGI
involved in response to heat	IGI IGI: 通过遗传相互作用推断	31874168	MGI
involved in response to heat	IMP IMP: 通过突变表型推断	29429934	MGI
involved in response to hormone	IMP IMP: 通过突变表型推断	32889171	MGI
involved in response to interleukin-17	IMP IMP: 通过突变表型推断	31853066	MGI
involved in response to light intensity	IMP IMP: 通过突变表型推断	32889171	MGI
involved in response to mechanical stimulus	IMP IMP: 通过突变表型推断	29429934	MGI
involved in response to metformin	IMP IMP: 通过突变表型推断	31874168	MGI
involved in response to odorant	IMP IMP: 通过突变表型推断	26273832	MGI
involved in response to pain	IMP IMP: 通过突变表型推断	29429934	MGI
involved in response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	31391512	MGI
involved in rhythmic behavior	IMP IMP: 通过突变表型推断	30816216	MGI
involved in social behavior	IMP IMP: 通过突变表型推断	26273832	MGI
involved in transmission of nerve impulse	IMP IMP: 通过突变表型推断	28184409	MGI
involved in vocalization behavior	IMP IMP: 通过突变表型推断	26273832	MGI
involved in walking behavior	IMP IMP: 通过突变表型推断	26273832	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axon	IDA IDA: 通过直接分析推断	25918374	MGI
is active in axon initial segment	IDA IDA: 通过直接分析推断	18509034	MGI
is active in cerebellar granule cell to Purkinje cell synapse	IDA IDA: 通过直接分析推断	32675284	MGI
is active in dendrite	IDA IDA: 通过直接分析推断	25918374	MGI
is active in excitatory synapse	IDA IDA: 通过直接分析推断	25918374	MGI
located in excitatory synapse	IDA IDA: 通过直接分析推断	25918374	MGI
located in excitatory synapse	IMP IMP: 通过突变表型推断	25918374	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	25918374	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	25918374	MGI
located in juxtaparanode region of axon	IDA IDA: 通过直接分析推断	11567047	MGI
located in membrane	IDA IDA: 通过直接分析推断	11567047	MGI
is active in neuron projection	IMP IMP: 通过突变表型推断	25918374	MGI
is active in neuron spine	IDA IDA: 通过直接分析推断	25918374	MGI
is active in neuronal cell body	IDA IDA: 通过直接分析推断	22133810	MGI
is active in plasma membrane raft	IDA IDA: 通过直接分析推断	25707359	MGI
is active in postsynapse	IDA IDA: 通过直接分析推断	32675284	MGI
is active in postsynapse	IMP IMP: 通过突变表型推断	32675284	MGI
is active in presynapse	IDA IDA: 通过直接分析推断	32675284	MGI
is active in presynapse	IMP IMP: 通过突变表型推断	32675284	MGI
is active in presynaptic active zone membrane	IDA IDA: 通过直接分析推断	25707359	MGI
is active in synapse	IDA IDA: 通过直接分析推断	25977097	MGI
is active in synapse	IPI IPI: 通过物理相互作用推断	32675284	MGI
part of voltage-gated potassium channel complex	IDA IDA: 通过直接分析推断	11567047	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

contactin-associated protein-like 2

cell recognition molecule Caspr2

重组 Cntnap2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75604	CASPR2 Protein, Mouse (HEK293, His)	NP_001004357.2 (A28-S1262)	≥95%

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02933	CNTNAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cntnap2	NCBI	NCBI:26047

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cntnap2 - contactin associated protein-like 2 Gene

关于 Cntnap2

功能概要

Cntnap2 基因产物(2)

重组 Cntnap2 蛋白

直系同源

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Cntnap2 - contactin associated protein-like 2 Gene

关于 Cntnap2

功能概要

Cntnap2 基因产物(2)

重组 Cntnap2 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

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Q

S

T

X

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