2. Gene
  3. Pnpla2 - patatin-like phospholipase domain containing 2 Gene

Pnpla2 - patatin-like phospholipase domain containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 patatin 样磷脂酶结构域 2

种属: Mus musculus

同用名: Atgl; TTS-2.2; 0610039C21Rik; 1110001C14Rik

基因 ID: 66853 | 基因类型: protein coding

关于 Pnpla2

Chromosome 7: 141,035,111-141,040,656 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 193 orthologues, 3 paralogues and is associated with 59 phenotypes. Biased expression in mammary gland adult (RPKM 647.4), subcutaneous fat pad adult (RPKM 559.9) and 14 other tissues.

功能概要

该基因编码的蛋白可启动甘油三酯脂肪酶活性。参与多个过程，包括酰基甘油代谢过程；甘油三酯螯合的负调节；和甘油三酯分解代谢过程的正调节。在细胞脂质分解代谢过程和脂滴组织的上游或内部起作用。位于胞质溶胶和脂滴中。与人 PNPLA2 同源（含有 2 的 patatin 样磷脂酶结构域）。 [由基因组资源联盟提供，2022 年 4 月]

Enables triglyceride Lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Acts upstream of or within cellular lipid catabolic process and lipid droplet organization. Located in cytosol and lipid droplet. Orthologous to human PNPLA2 (patatin like Phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla2 基因产物(2)

mRNA Protein Name
NM_025802.3 NP_080078.2 patatin-like phospholipase domain-containing protein 2 isoform 2
NM_001163689.1 NP_001157161.1 patatin-like phospholipase domain-containing protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16679289 MGI
enables triacylglycerol lipase activity IDA
IDA: 通过直接分析推断
15337759 MGI
enables triacylglycerol lipase activity IMP
IMP: 通过突变表型推断
16675698 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular lipid catabolic process IMP
IMP: 通过突变表型推断
26427354 MGI
involved in diacylglycerol biosynthetic process IDA
IDA: 通过直接分析推断
23066022 MGI
acts upstream of or within lipid droplet organization IMP
IMP: 通过突变表型推断
23297223 MGI
involved in lipid storage IMP
IMP: 通过突变表型推断
21148142 MGI
involved in negative regulation of sequestering of triglyceride IDA
IDA: 通过直接分析推断
16679289 MGI
involved in positive regulation of triglyceride catabolic process IDA
IDA: 通过直接分析推断
16679289 MGI
involved in triglyceride catabolic process IDA
IDA: 通过直接分析推断
23066022 MGI
acts upstream of or within triglyceride catabolic process IMP
IMP: 通过突变表型推断
17074755 MGI
involved in triglyceride catabolic process IMP
IMP: 通过突变表型推断
16675698 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15337759 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17074755 MGI
located in lipid droplet IDA
IDA: 通过直接分析推断
15550674 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pnpla2 蛋白结构

Pat_PNPLA2

Pat_PNPLA2: cd07220 (3 - 251)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
蛋白主名 其他名称

patatin-like phospholipase domain-containing protein 2

adipose triglyceride lipase

calcium-independent phospholipase A2-zeta

desnutrin

iPLA2-zeta

transport-secretion protein

triglyceride hydrolase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10791 PNPLA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10792 Pnpla2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10793 PNPLA2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pnpla2 NCBI NCBI:57104
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