1. Gene
  2. SSR1 - signal sequence receptor subunit 1 Gene

SSR1 - signal sequence receptor subunit 1 Gene

中文名称:信号序列受体亚基 1

种属: Homo sapiens

同用名: TRAPA

基因 ID: 6745 | 基因类型: protein coding

关于 SSR1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,281,143-7,313,199 (from NCBI)

This gene has 11 transcripts (splice variants) and 235 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), appendix (RPKM 16.5) and 25 other tissues.

功能概要

信号序列受体 (SSR) 是一种糖基化内质网 (ER) 膜受体,与跨 ER 膜的蛋白质易位相关。 SSR 由 2 个亚基组成,一个由该基因编码的 34-kD 糖蛋白和一个 22-kD 糖蛋白。由于复杂的替代聚腺苷酸化,该基因产生了几种 mRNA 种类。该基因的不同寻常之处在于它利用了大部分非规范的 polyA 信号序列阵列。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2014 年 5 月]

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SSR1 基因产物(2)

mRNA Protein Name
NM_001292008.2 NP_001278937.1 translocon-associated protein subunit alpha isoform 2 precursor
NM_003144.5 NP_003135.2 translocon-associated protein subunit alpha isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17380188 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SSR1 蛋白结构

TRAP_alpha

TRAP_alpha: Translocon-associated protein (TRAP), alpha subunit (1 - 285)

  • 0
  • 100
  • 200
  • 286 a.a.
蛋白主名 其他名称

translocon-associated protein subunit alpha

SSR alpha subunit

SSR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SSR1 P43307 CANX Homo sapiens P27824
Anti Bait CoIP
22314232
种属内
SSR1 P43307 SERPINA1 Homo sapiens P01009
Anti Bait CoIP
17380188
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SSR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77493 Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) P43307-1/NP_003135.2 (V19-T207) ≥95%

关联疾病

疾病名称 别名
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Benign Pleural Mesothelioma

Mesothelioma Of Pleura

Benign Neoplasm Of Mesothelial Tissue Of Pleura

Pleural Malignant Mesothelioma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SSR1 VGNC VGNC:35319
Rattus norvegicus SSR1 RGD RGD:1310961
Mus musculus SSR1 MGD MGI:105082
Felis catus SSR1 VGNC VGNC:65708
Macaca mulatta SSR1 VGNC VGNC:77888
Canis familiaris SSR1 VGNC VGNC:46837
Others SSR1 NCBI