TFAP2C - transcription factor AP-2 gamma Gene

中文名称：转录因子 AP-2 γ

种属: Homo sapiens

同用名: ERF1; TFAP2G; hAP-2g; AP2-GAMMA

基因 ID: 7022 | 基因类型: protein coding

关于 TFAP2C

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,629,306-56,639,283 (from NCBI)

This gene has 2 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in skin (RPKM 24.1), placenta (RPKM 10.9) and 6 other tissues.

功能概要

由该基因编码的蛋白质是一种序列特异性 DNA 结合转录因子，参与多个发育基因的激活。编码的蛋白质可以与其他家族成员一起作为同二聚体或异二聚体，并在视黄酸介导的分化过程中被诱导。它在眼睛、面部、体壁、四肢和神经管的发育中发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with Other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

TFAP2C 基因产物(1)

mRNA	Protein	Name
NM_003222.4	NP_003213.1	transcription factor AP-2 gamma

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	12072434	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	11278550	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	11278550	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	24413532	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11694877	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in male gonad development	IEP IEP: 通过表达模式推断	17848411	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: 通过突变表型推断	24413532	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	22735262	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	24413532	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFAP2C 蛋白结构

TF_AP-2

0
100
200
300
400
450 a.a.

蛋白主名

其他名称

transcription factor AP-2 gamma

activating enhancer-binding protein 2 gamma

TFAP2C 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TFAP2C	Q92754	UBE2I	Homo sapiens	P63279	Y2H	12072434
种属内	TFAP2C	Q92754	UBE2I	Homo sapiens	P63279	Pull Down	24835590
种属内	TFAP2C	Q92754	UBE2I	Homo sapiens	P63279	Anti Tag CoIP	24835590
种属内	TFAP2C	Q92754	CITED2	Homo sapiens	Q99967	Y2H	12586840

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TFAP2C 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76728	AP-2 gamma/TFAP2C Protein, Human (His)	Q92754-1 (L128-V223)	≥95%

TFAP2C 抗体

目录号	产品名	应用	反应物种
HY-P81397	Transcription Factor AP 2 gamma Antibody (YA1142)	IHC-P	Human

关联疾病

疾病名称

别名

Extragonadal Seminoma

Primary Extragonadal Seminoma

Char Syndrome

Patent Ductus Arteriosus With Facial Dysmorphism And Abnormal Fifth Digits

CHAR

Seminoma

Seminoma, Pure

Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome	BOFS
Bof Syndrome	Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome
Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome	Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging
Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging	Bofs Syndrome
Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Brain Germinoma

Intracranial Germinoma

Germinoma Of The Brain

Spermatocytoma

Spermatocytic Seminoma

Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor	Paediatric Germ Cell Cancer
Paediatric Germ Cell Neoplasm	Pediatric Germ Cell Cancer
Pediatric Germ Cell Neoplasm

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14410	TFAP2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TFAP2C	VGNC	VGNC:47285
Bos taurus	TFAP2C	VGNC	VGNC:35778
Rattus norvegicus	TFAP2C	RGD	RGD:1303185
Mus musculus	TFAP2C	MGD	MGI:106032
Macaca mulatta	TFAP2C	VGNC	VGNC:78322
Felis catus	TFAP2C	VGNC	VGNC:66110
Others	TFAP2C	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TFAP2C - transcription factor AP-2 gamma Gene

关于 TFAP2C

功能概要

TFAP2C 基因产物(1)

TFAP2C 蛋白结构

TFAP2C 蛋白互作信息

重组 TFAP2C 蛋白

TFAP2C 抗体

关联疾病

直系同源

热门区域

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TFAP2C - transcription factor AP-2 gamma Gene

关于 TFAP2C

功能概要

TFAP2C 基因产物(1)

TFAP2C 蛋白结构

TFAP2C 蛋白互作信息

重组 TFAP2C 蛋白

TFAP2C 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z