TIMP4 - TIMP metallopeptidase inhibitor 4 Gene

中文名称：TIMP 金属肽酶抑制因子 4

种属: Homo sapiens

同用名: TIMP-4

基因 ID: 7079 | 基因类型: protein coding

关于 TIMP4

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,153,068-12,158,912 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Biased expression in fat (RPKM 76.2) and brain (RPKM 10.2).

功能概要

该基因属于 TIMP 基因家族。由该基因家族编码的蛋白质是基质金属蛋白酶的抑制剂，基质金属蛋白酶是一组参与细胞外基质降解的肽酶。由该基因编码的分泌的、含有 netrin 结构域的蛋白质参与血小板聚集和募集的调节，并可能在激素调节和子宫内膜组织重塑中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the Matrix Metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

TIMP4 基因产物(1)

mRNA	Protein	Name
NM_003256.4	NP_003247.1	metalloproteinase inhibitor 4 precursor

TIMP4 蛋白结构

TIMP

0
100
200
224 a.a.

蛋白主名

其他名称

metalloproteinase inhibitor 4

tissue inhibitor of metalloproteinase 4

重组 TIMP4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71368	TIMP-4 Protein, Human (HEK293, His)	Q99727 (C30-P224)	≥95%

关联疾病

疾病名称

别名

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Rheumatic Heart Disease

Rheumatic Carditis	Rheumatic Congestive Heart Failure
Congestive Rheumatic Heart Failure	Rheumatic Heart Failure
RHD	Rheumatic Fever Inactive Or Quiescent With Heart Disease
Rheumatic Fever Inactive Or Quiescent With Carditis	Organ Rheumatic Heart Disease
Organic Rheumatic Heart Disease	Inactive Rheumatic Heart Disease
Rheumatic Heart	Rheumatic Fever Inactive Or Quiescent With Pancarditis
Rhd - [Rheumatic Heart Disease]	Rheumatic Cardiac Hypertrophy
Rheumatic Fever	Inactive Or Quiescent With Cardiac Hypertrophy
Rheumatic Pancarditis	Inactive Rhd - [Rheumatic Heart Disease]
Rheumatic Nonischaemic Cardiopathy

Sorsby Fundus Dystrophy

SFD	Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Sorsby'S Fundus Dystrophy	Macular Dystrophy, Hemorrhagic
Hemorrhagic Macular Dystrophy	Pseudoinflammatory Fundus Dystrophy Of Sorsby
Sorsby'S Pseudoinflammatory Macular Dystrophy	Sorsby Pseudoinflammatory Fundus Dystrophy
Dystrophy, Fundus, Sorsby

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14541	TIMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TIMP4	VGNC	VGNC:47378
Mus musculus	TIMP4	MGD	MGI:109125
Rattus norvegicus	TIMP4	RGD	RGD:69077
Bos taurus	TIMP4	VGNC	VGNC:35873
Felis catus	TIMP4	VGNC	VGNC:66194
Macaca mulatta	TIMP4	VGNC	VGNC:78358
Others	TIMP4	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TIMP4 - TIMP metallopeptidase inhibitor 4 Gene

关于 TIMP4

功能概要

TIMP4 基因产物(1)

TIMP4 蛋白结构

重组 TIMP4 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TIMP4 - TIMP metallopeptidase inhibitor 4 Gene

关于 TIMP4

功能概要

TIMP4 基因产物(1)

TIMP4 蛋白结构

重组 TIMP4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z