2. Gene
  3. ICAM5 - intercellular adhesion molecule 5 Gene

ICAM5 - intercellular adhesion molecule 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞间粘附分子 5

种属: Homo sapiens

同用名: TLN; TLCN

基因 ID: 7087 | 基因类型: protein coding

关于 ICAM5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,289,952-10,296,778 (from NCBI)

This gene has 5 transcripts (splice variants), 91 orthologues and 4 paralogues. Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue.

功能概要

该基因编码的蛋白质是细胞间粘附分子 (ICAM) 家族的成员。所有 ICAM 蛋白都是 I 型跨膜糖蛋白，包含 2-9 个免疫球蛋白样 C2 型结构域，并与白细胞粘附 LFA-1 蛋白结合。这种蛋白质在端脑神经元的表面表达，并表现出两种类型的粘附活性，即神经元之间的同嗜结合和神经元与白细胞之间的异嗜结合。它可能是正常发育过程中神经元-小胶质细胞相互作用的重要组成部分，或作为神经退行性疾病的一部分。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

ICAM5 基因产物(1)

mRNA Protein Name
NM_003259.4 NP_003250.3 intercellular adhesion molecule 5 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16820411 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ICAM5 蛋白结构

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (35 - 122)

Ig_2

Ig_2: Immunoglobulin domain (133 - 202)

Ig_2

Ig_2: Immunoglobulin domain (324 - 392)

Ig_3

Ig_3: Immunoglobulin domain (423 - 474)

Ig_2

Ig_2: Immunoglobulin domain (506 - 569)

Ig_2

Ig_2: Immunoglobulin domain (686 - 741)

Ig_2

Ig_2: Immunoglobulin domain (754 - 827)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 924 a.a.
蛋白主名 其他名称

intercellular adhesion molecule 5

ICAM-5

ICAM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Validated Y2H
32814053
种属内
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Y2H Array
32814053
种属内
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Y2H Pooling
32814053
种属间
ICAM5 Q9UMF0 ACTN1 Gallus gallus P05094
Pull Down
16820411
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ICAM5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74869 ICAM-5 Protein, Human (HEK293, His) Q9UMF0 (E32-P834) ≥95%
HY-P74870 ICAM-5 Protein, Human (539a.a, HEK293, Fc) Q9UMF0 (E32-E570) ≥95%
HY-P74871 ICAM-5 Protein, Human (101a.a, HEK293, Fc) Q9UMF0 (E32-Q132) ≥95%

关联疾病

疾病名称 别名
Acute Flaccid Myelitis
Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis

Conjunctivitis, Acute Hemorrhagic

Apollo Disease

Epidemic Hemorrhagic Conjunctivitis

Viral Conjunctiva Disorder

Viral Conjunctivitis Nos
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06516 ICAM5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ICAM5 MGD MGI:109430
Bos taurus ICAM5 VGNC VGNC:30025
Felis catus ICAM5 VGNC VGNC:67688
Rattus norvegicus ICAM5 RGD RGD:1305039
Canis familiaris ICAM5 VGNC VGNC:41857
Others ICAM5 NCBI
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