NR2C1 - nuclear receptor subfamily 2 group C member 1 Gene

中文名称：核受体亚家族 2 C 组成员 1

种属: Homo sapiens

同用名: TR2

关于 NR2C1

功能概要

该基因编码的核激素受体具有高度保守的 DNA 结合域 (DBD) 、可变铰链区和羧基末端配体结合域 (LBD) ，这是类固醇/甲状腺激素受体超家族所有成员的典型特征。该蛋白还属于配体诱导转录因子大家族，通过结合靶基因启动子内的特定 DNA 序列来调节基因表达。已经描述了多个选择性剪接的转录本变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/Thyroid Hormone Receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]