TTF1 - transcription termination factor 1 Gene

中文名称：转录终止因子 1

种属: Homo sapiens

同用名: TTF-1; TTF-I

关于 TTF1

功能概要

该基因编码一个转录终止因子，该因子定位于核仁，在核糖体基因转录中起着关键作用。编码的蛋白质通过结合前 rRNA 编码区下游的 Sal 盒终止子元件来介导 RNA 聚合酶 I 转录的终止。已经观察到该基因编码多种亚型的可变剪接转录物变体。该基因与另一个基因 NK2 同源框 1 (也称为甲状腺转录因子 1) 共享符号/别名“TFF1”，它在甲状腺特异性基因表达的调节中发挥作用。[RefSeq 提供，2011 年 4 月]

This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]