2. Gene
  3. SCG2 - secretogranin II Gene

SCG2 - secretogranin II Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：分泌素 II

种属: Homo sapiens

同用名: SN; CHGC; EM66; SgII

基因 ID: 7857 | 基因类型: protein coding

关于 SCG2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,596,940-223,602,361 (from NCBI)

This gene has 3 transcripts (splice variants) and 254 orthologues. Biased expression in adrenal (RPKM 212.1), brain (RPKM 97.1) and 4 other tissues.

功能概要

由该基因编码的蛋白质是神经内分泌蛋白嗜铬粒蛋白/分泌粒蛋白家族的成员。对啮齿类动物的研究表明，全长蛋白 secretogranin II 参与将肽激素和神经肽包装或分类到分泌囊泡中。全长蛋白被切割产生活性肽分泌神经素，它对特定细胞类型发挥趋化作用，以及 EM66，其功能未知。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide Hormones and Neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

SCG2 基因产物(1)

mRNA Protein Name
NM_003469.5 NP_003460.2 secretogranin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemoattractant activity IDA
IDA: 通过直接分析推断
9473216 GOA
enables cytokine activity IDA
IDA: 通过直接分析推断
14970115 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IDA
IDA: 通过直接分析推断
14970115 GOA
involved in angiogenesis IDA
IDA: 通过直接分析推断
14970115 GOA
involved in eosinophil chemotaxis IDA
IDA: 通过直接分析推断
9473216 GOA
involved in induction of positive chemotaxis IDA
IDA: 通过直接分析推断
9473216 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9473216 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: 通过直接分析推断
14970115 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14970115 GOA
involved in positive chemotaxis IDA
IDA: 通过直接分析推断
9473216 GOA
involved in positive regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
14970115 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
9473216 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCG2 蛋白结构

Granin

Granin: Granin (chromogranin or secretogranin) (27 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
蛋白主名 其他名称

secretogranin-2

chromogranin-C

重组 SCG2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70134 Secretogranin-2 Protein, Human (HEK293, His) P13521 (S29-M617) ≥95%

关联疾病

疾病名称 别名
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm
Insulinoma

Islet Cell Adenoma

Insulin-Producing Tumor Of Islet Cells

Adenoma Islet Cell

Islet Cell Tumor

Experimental Organism Islet Cell Adenoma Neoplasm
Ganglioneuroma
Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe
Collagenous Colitis

Colitis, Collagenous

Microscopic Colitis, Collagenous Type
Malignant Pheochromocytoma

Pheochromocytoma, Malignant
Adrenal Medulla Cancer

Adrenal Medulla Neoplasm

Adrenal Medulla Tumor

Malignant Neoplasm Of Adrenal Medulla

Malignant Tumor Of The Adrenal Medulla

Adrenal Medulla Carcinoma

Neoplasm Of Adrenal Medulla
Neuroendocrine Tumor

Neuroendocrine Neoplasm

Neuroendocrine Tumors

Carcinoma, Neuroendocrine
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12501 SCG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SCG2 VGNC VGNC:64908
Mus musculus SCG2 MGD MGI:103033
Canis familiaris SCG2 VGNC VGNC:45905
Rattus norvegicus SCG2 RGD RGD:3626
Bos taurus SCG2 VGNC VGNC:34332
Macaca mulatta SCG2 VGNC VGNC:76977
Others SCG2 NCBI
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