2. Gene
  3. Kiss1r - KISS1 receptor Gene

Kiss1r - KISS1 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：K ISS1 受体

种属: Rattus norvegicus

同用名: Gpr54

基因 ID: 78976 | 基因类型: protein coding

关于 Kiss1r

Primary_assembly 7: 9,785,135-9,788,793 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 135 orthologues, 14 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 5.8), Testes (RPKM .9) and 1 other tissue.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联肽受体活性和神经肽结合活性。参与多种过程，包括花生四烯酸分泌；细胞通讯的正向调节；和应力纤维组装的正向调节。位于膜内。该基因的人类直系同源物与中枢性性早熟有关 1；性腺功能减退症;和低促性腺激素性腺功能减退症 8 伴或不伴嗅觉缺失。与人类 KISS1R（KISS1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled peptide receptor activity and neuropeptide binding activity. Involved in several processes, including arachidonic acid secretion; positive regulation of cell communication; and positive regulation of stress fiber assembly. Located in membrane. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Kiss1r 基因产物(2)

mRNA Protein Name
NM_001301151.1 NP_001288080.1 kiSS-1 receptor isoform 2
NM_023992.2 NP_076482.2 kiSS-1 receptor isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled peptide receptor activity IPI
IPI: 通过物理相互作用推断
11457843 RGD
enables neuropeptide binding IDA
IDA: 通过直接分析推断
11414709 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
16222076 RGD
involved in arachidonate secretion IDA
IDA: 通过直接分析推断
11457843 RGD
involved in calcium-mediated signaling IMP
IMP: 通过突变表型推断
16222076 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11457843 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
11457843 RGD
involved in positive regulation of hormone secretion IDA
IDA: 通过直接分析推断
11457843 RGD
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
11457843 RGD
involved in positive regulation of synaptic transmission IMP
IMP: 通过突变表型推断
16222076 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Kiss1r 蛋白结构

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (42 - 333)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (43 - 69)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (76 - 102)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (114 - 144)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (156 - 176)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (200 - 229)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (255 - 285)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (301 - 326)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

kiSS-1 receptor

G protein-coupled receptor 54

G-protein coupled receptor OT7T175

kiSS-

kiSS-1R

kisspeptins receptor

metastin receptor

orphan G protein-coupled receptor GPR54

rOT7T175

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P0076A TAK-448 acetate 99.70% Phase 2
HY-P0076 TAK-448 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2161B TAK-683 acetate 99.91% 否
HY-P2161 TAK-683 / 否
HY-P2161A TAK-683 TFA / 否
HY-P2191 KISS1-305 / 否
HY-RS07316 KISS1R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07317 Kiss1r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07318 Kiss1r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kiss1r NCBI NCBI:84634
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