GGCT - gamma-glutamylcyclotransferase Gene

中文名称：γ-谷氨酰环转移酶

种属: Homo sapiens

同用名: GGC; GCTG; CRF21; C7orf24

关于 GGCT

功能概要

该基因编码的蛋白质催化 γ-谷氨酰二肽形成 5-氧代脯氨酸，这是谷胱甘肽分解代谢的倒数第二步，可能在谷胱甘肽稳态中发挥关键作用。编码的蛋白质也可能在细胞增殖中发挥作用，该基因的表达是癌症的潜在标志物。该基因的假基因位于 5 号染色体的长臂和 2 号和 20 号染色体的短臂上。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for Cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]