2. Gene
  3. Acvr1 - activin A receptor type 1 Gene

Acvr1 - activin A receptor type 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：激活素 A 受体 1 型

种属: Rattus norvegicus

基因 ID: 79558 | 基因类型: protein coding

关于 Acvr1

Primary_assembly 3: 42,978,561-43,098,241 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 11 phenotypes. Biased expression in Heart (RPKM 32.9), Kidney (RPKM 31.) and 9 other tissues.

功能概要

激活 I 型激活素受体活性。参与细胞对糖皮质激素刺激的反应；骨骼肌组织发育的调节；和转化生长因子β受体信号通路。作用于泌尿生殖系统发育的上游或内部。激活素受体复合物的一部分。该基因的人类直系同源物与进行性骨化性纤维发育不良有关。与人类 ACVR1（激活素 A 受体 1 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (Activin A receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1 基因产物(1)

mRNA Protein Name
NM_024486.1 NP_077812.1 activin receptor type-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables activin receptor activity, type I IDA
IDA: 通过直接分析推断
8248234 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucocorticoid stimulus IEP
IEP: 通过表达模式推断
16150914 RGD
involved in regulation of skeletal muscle tissue development IEP
IEP: 通过表达模式推断
12968668 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
12968668 RGD
acts upstream of or within urogenital system development IMP
IMP: 通过突变表型推断
11376112 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of activin receptor complex IDA
IDA: 通过直接分析推断
8248234 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acvr1 蛋白结构

Activin_recp

Activin_recp: pfam01064 (51 - 120)

TGF_beta_GS

TGF_beta_GS: pfam08515 (197 - 224)

STKc_ACVR1_ALK1

STKc_ACVR1_ALK1: cd14142 (220 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 528 a.a.
蛋白主名 其他名称

activin receptor type-1

ACTR-I

ALK2-B

SKR1

TGF-B superfamily receptor type I

TSR-I

activin A receptor, type I

activin receptor type I

activin type I receptor

serine/threonine-protein kinase receptor R1

重组 Acvr1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75538 ACVR1 Protein, Rat (HEK293, hFc) P80201 (M21-E123) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109179 Itacnosertib Inhibitor 99.06% Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-109179A Itacnosertib (hydrocholide) Inhibitor 99.43% 否
HY-RS00236 ACVR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00237 Acvr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00238 Acvr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W064657 Momelotinib dihydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr1 NCBI NCBI:90
Canis familiaris Acvr1 NCBI NCBI:478757
Macaca fascicularis Acvr1 NCBI NCBI:102134051
Mus musculus Acvr1 NCBI NCBI:11477
Macaca mulatta Acvr1 NCBI NCBI:697935
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