TFPI2 - tissue factor pathway inhibitor 2 Gene

中文名称：组织因子通路抑制因子 2

种属: Homo sapiens

同用名: PP5; REF1; TFPI-2

基因 ID: 7980 | 基因类型: protein coding

关于 TFPI2

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,885,396-93,890,753 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 13 paralogues. Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9).

功能概要

该基因编码 Kunitz 型丝氨酸蛋白酶抑制剂家族的成员。该蛋白可以抑制多种丝氨酸蛋白酶，包括因子 VIIa/组织因子、因子 Xa、纤溶酶、胰蛋白酶、胰凝乳蛋白酶和血浆激肽释放酶。该基因已被确定为多种癌症的抑癌基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, Factor Xa, plasmin, trypsin, chymotryspin and plasma Kallikrein. This gene has been identified as a tumor suppressor gene in several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

TFPI2 基因产物(3)

mRNA	Protein	Name
NM_001271003.2	NP_001257932.1	tissue factor pathway inhibitor 2 isoform 2 precursor
NM_001271004.2	NP_001257933.1	tissue factor pathway inhibitor 2 isoform 3 precursor
NM_006528.4	NP_006519.1	tissue factor pathway inhibitor 2 isoform 1 precursor

TFPI2 蛋白结构

Kunitz_BPTI

0
100
200
235 a.a.

蛋白主名

其他名称

tissue factor pathway inhibitor 2

placental protein 5

重组 TFPI2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71358	TFPI2 Protein, Human (HEK293, His)	P48307 (D23-K213)	≥95%
HY-P71358A	TFPI2 Protein, Human (HEK293, C-His)	P48307 (D23-K213)	≥95%

关联疾病

疾病名称

别名

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Choriocarcinoma

Chorioepithelioma

Hellp Syndrome

Hemolysis, Elevated Liver Enzymes, Lowered Platelets	Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome	Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]
Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Ovarian Clear Cell Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14428	TFPI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TFPI2	VGNC	VGNC:47302
Rattus norvegicus	TFPI2	RGD	RGD:628629
Felis catus	TFPI2	VGNC	VGNC:66124
Macaca mulatta	TFPI2	VGNC	VGNC:78329
Mus musculus	TFPI2	MGD	MGI:108543
Bos taurus	TFPI2	VGNC	VGNC:35794
Others	TFPI2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TFPI2 - tissue factor pathway inhibitor 2 Gene

关于 TFPI2

功能概要

TFPI2 基因产物(3)

TFPI2 蛋白结构

重组 TFPI2 蛋白

关联疾病

直系同源

热门区域

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TFPI2 - tissue factor pathway inhibitor 2 Gene

关于 TFPI2

功能概要

TFPI2 基因产物(3)

TFPI2 蛋白结构

重组 TFPI2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z