1. Gene
  2. CLMP - CXADR like membrane protein Gene

CLMP - CXADR like membrane protein Gene

中文名称:CXADR 样膜蛋白

种属: Homo sapiens

同用名: ACAM; ASAM; CSBM; CSBS

基因 ID: 79827 | 基因类型: protein coding

关于 CLMP

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:123,069,872-123,195,248 (from NCBI)

This gene has 4 transcripts (splice variants), 397 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 45.1), endometrium (RPKM 20.9) and 17 other tissues.

功能概要

该基因编码一种 I 型跨膜蛋白,该蛋白定位于内皮细胞和上皮细胞之间的连接复合物,可能在细胞间粘附中发挥作用。该基因在白色脂肪组织中的表达与脂肪细胞的成熟和肥胖的发展有关。该基因对于正常的肠道发育也是必不可少的,该基因的突变与先天性短肠综合征有关。[RefSeq 提供,2015 年 8 月]

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

CLMP 基因产物(1)

mRNA Protein Name
NM_024769.5 NP_079045.1 CXADR-like membrane protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in digestive tract development IMP
IMP: 通过突变表型推断
22155368 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
22155368 GOA
located in cytoplasmic microtubule IDA
IDA: 通过直接分析推断
23264731 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CLMP 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (20 - 123)

Ig_2

Ig_2: Immunoglobulin domain (138 - 225)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

CXADR-like membrane protein

CAR-like membrane protein

重组 CLMP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7609 ASAM/CLMP Protein, Human (HEK293, His) Q9H6B4 (T19-M233) ≥95%

关联疾病

疾病名称 别名
Congenital Short Bowel Syndrome

CSBS

Congenital Short Bowel

Congenital Short Bowel And Malrotation Syndrome

Csbm

Bowel, Short, Syndrome, Congenital

Intestinal Pseudo-Obstruction

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction

Chronic Intestinal Pseudo-Obstruction

Cipo

Neuronal Intestinal Dysplasia

Hollow Visceral Myopathy

Familial Visceral Neuropathy

Paralytic Ileus

Intestinal Pseudoobstruction

Chronic Idiopathic Intestinal Pseudo-Obstruction

Ciip

Congenital Short Bowel Syndrome

Enteric Neuropathy

Familial Visceral Myopathy

Ipo

Pseudo-Obstruction Of Intestine

Pseudointestinal Obstruction Syndrome

Pseudoobstructive Syndrome

Congenital Idiopathic Intestinal Pseudoobstruction

Visceral Myopathy, Familial

Short Bowel Syndrome

Short Gut Syndrome

Acquired Short Bowel Syndrome

Secondary Short Bowel Syndrome

Short Bowel Nos

Interstitial Myocarditis
Testicular Thecoma
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CLMP VGNC VGNC:71328
Felis catus CLMP VGNC VGNC:60967
Mus musculus CLMP MGD MGI:1918816
Bos taurus CLMP VGNC VGNC:50091
Rattus norvegicus CLMP RGD RGD:708569
Others CLMP NCBI