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  2. TREML2 - triggering receptor expressed on myeloid cells like 2 Gene

TREML2 - triggering receptor expressed on myeloid cells like 2 Gene

中文名称:在骨髓细胞上表达的触发受体样 2

种属: Homo sapiens

同用名: TLT2; TLT-2; C6orf76; dJ238O23.1

基因 ID: 79865 | 基因类型: protein coding

关于 TREML2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,189,749-41,201,149 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 5.6), lymph node (RPKM 5.1) and 6 other tissues.

功能概要

TREML2 位于 6 号染色体上的基因簇中,具有单个 Ig 可变 (IgV) 域激活受体 TREM1 (MIM 605085) 和 TREM2 (MIM 605086) ,但它具有不同的结构和功能特性 (Allcock 等人,2003 [PubMed 12645956]) .[OMIM 提供,2008 年 3 月]

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

TREML2 基因产物(1)

mRNA Protein Name
NM_024807.4 NP_079083.2 trem-like transcript 2 protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18650384 GOA
enables signaling receptor activity IDA
IDA: 通过直接分析推断
18650384 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IDA
IDA: 通过直接分析推断
18650384 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
18650384 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TREML2 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (28 - 114)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
蛋白主名 其他名称

trem-like transcript 2 protein

triggering receptor expressed on myeloid cells-like protein 2

重组 TREML2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71383 TREML2 Protein, Human (HEK293, Fc) Q5T2D2 (G19-S268) ≥95%

关联疾病

疾病名称 别名
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TREML2 RGD RGD:1587039
Canis familiaris TREML2 VGNC VGNC:47795
Mus musculus TREML2 MGD MGI:2147038
Macaca mulatta TREML2 VGNC VGNC:79309
Bos taurus TREML2 VGNC VGNC:36301
Others TREML2 NCBI