SCD5 - stearoyl-CoA desaturase 5 Gene

中文名称：硬脂酰辅酶 A 去饱和酶 5

种属: Homo sapiens

同用名: SCD2; SCD4; ACOD4; FADS4; HSCD5; DFNA79

关于 SCD5

功能概要

硬脂酰辅酶 A 去饱和酶 (SCD; EC 1.14.99.5) 是内质网的一种整合膜蛋白，可催化饱和脂肪酸形成单不饱和脂肪酸。 SCD 可能是能量代谢的关键调节因子，在肥胖和血脂异常中起作用。四种 SCD 亚型，Scd1 到 Scd4，已在小鼠中鉴定出来。相比之下，在人类中仅鉴定出 2 种 SCD 亚型，SCD1 (MIM 604031) 和 SCD5。 SCD1 与所有 4 种小鼠 SCD 亚型以及大鼠 Scd1 和 Scd2 共享约 85% 的氨基酸同一性。相比之下，SCD5 与啮齿动物 SCD 的同源性有限，并且似乎是灵长类动物独有的 (Wang 等人，2005 [PubMed 15907797]) 。[OMIM 提供，2008 年 3 月]

Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]