2. Gene
  3. TRIM45 - tripartite motif containing 45 Gene

TRIM45 - tripartite motif containing 45 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 45

种属: Homo sapiens

同用名: RNF99

基因 ID: 80263 | 基因类型: protein coding

关于 TRIM45

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,111,060-117,123,927 (from NCBI)

This gene has 5 transcripts (splice variants), 185 orthologues and 80 paralogues. Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues.

功能概要

该基因编码三联基序家族的一个成员。所编码的蛋白质可作为丝裂原活化蛋白激酶途径的转录抑制因子发挥作用。已经描述了选择性剪接的转录变体。[RefSeq 提供，2009 年 3 月]

This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

TRIM45 基因产物(2)

mRNA Protein Name
NM_001145635.2 NP_001139107.1 tripartite motif-containing protein 45 isoform 2
NM_025188.4 NP_079464.2 tripartite motif-containing protein 45 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
28542145 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
36681779 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
36681779 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
36681779 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
36681779 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM45 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 55)

zf-B_box

zf-B_box: B-box zinc finger (133 - 175)

zf-B_box

zf-B_box: B-box zinc finger (188 - 224)

Filamin

Filamin: Filamin/ABP280 repeat (397 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 45

ring finger protein 99

关联疾病

疾病名称 别名
Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis
Birdshot Chorioretinopathy

Birdshot Chorioretinitis

Bscr

Birdshot Retinochoroiditis

Birdshot Retinochoroidopathy

Vitiliginous Choroiditis

Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15049 TRIM45 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRIM45 VGNC VGNC:79169
Felis catus TRIM45 VGNC VGNC:66541
Bos taurus TRIM45 VGNC VGNC:36337
Mus musculus TRIM45 MGD MGI:1918187
Canis familiaris TRIM45 VGNC VGNC:47824
Rattus norvegicus TRIM45 RGD RGD:1309168
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