ADAM33 - ADAM metallopeptidase domain 33 Gene

中文名称：ADAM 金属肽酶结构域 33

种属: Homo sapiens

同用名: C20orf153; DJ964F7.1

基因 ID: 80332 | 基因类型: protein coding

关于 ADAM33

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,667,975-3,682,010 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues.

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。这种蛋白质是一种 I 型跨膜蛋白，与哮喘和支气管高反应性有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

ADAM33 基因产物(3)

mRNA	Protein	Name
NM_001282447.3	NP_001269376.1	disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor
NM_025220.5	NP_079496.1	disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein
NM_153202.4	NP_694882.1	disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM33 蛋白结构

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
813 a.a.

蛋白主名

其他名称

disintegrin and metalloproteinase domain-containing protein 33

ADAM 33

关联疾病

疾病名称

别名

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Near-Fatal Asthma

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Intrinsic Asthma

Non-Atopic Asthma

Chronic Asthma

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00284	ADAM33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ADAM33	VGNC	VGNC:59583
Rattus norvegicus	ADAM33	RGD	RGD:1305278
Macaca mulatta	ADAM33	VGNC	VGNC:69409
Canis familiaris	ADAM33	VGNC	VGNC:37585
Mus musculus	ADAM33	MGD	MGI:1341813
Bos taurus	ADAM33	VGNC	VGNC:25611
Others	ADAM33	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADAM33 - ADAM metallopeptidase domain 33 Gene

关于 ADAM33

功能概要

ADAM33 基因产物(3)

ADAM33 蛋白结构

关联疾病

直系同源

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ADAM33 - ADAM metallopeptidase domain 33 Gene

关于 ADAM33

功能概要

ADAM33 基因产物(3)

ADAM33 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z