2. Gene
  3. MPIG6B - megakaryocyte and platelet inhibitory receptor G6b Gene

MPIG6B - megakaryocyte and platelet inhibitory receptor G6b Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：巨核细胞和血小板抑制受体 G6b

种属: Homo sapiens

同用名: G6b; NG31; G6b-B; THAMY; C6orf25

基因 ID: 80739 | 基因类型: protein coding

关于 MPIG6B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,720,296-31,726,714 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 89 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 2.2), bone marrow (RPKM 1.5) and 14 other tissues.

功能概要

该基因是免疫球蛋白 (Ig) 超家族的成员，位于主要组织相容性复合体 (MHC) III 类区域。由该基因编码的蛋白质是一种糖基化的质膜结合细胞表面受体，但在分泌之前在内质网和高尔基体中发现了由一些转录变体编码的可溶性亚型。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MPIG6B 基因产物(6)

mRNA Protein Name
NM_025260.4 NP_079536.2 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-A precursor
NM_138272.3 NP_612116.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-B precursor
NM_138273.3 NP_612117.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-C precursor
NM_138274.3 NP_612118.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-D precursor
NM_138275.3 NP_612119.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-E precursor
NM_138277.3 NP_612121.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-G precursor

MPIG6B 蛋白结构

G6B

G6B: G6B family (18 - 241)

  • 0
  • 100
  • 200
  • 241 a.a.
蛋白主名 其他名称

megakaryocyte and platelet inhibitory receptor G6b

immunoglobulin receptor

重组 MPIG6B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75784 G6B Protein, Human (HEK293, Fc) O95866-1/NP_612116.1 (N18-Q146) ≥95%
HY-P75785 G6B Protein, Human (HEK293, His) O95866-1/NP_612116.1 (N18-Q142) ≥95%

关联疾病

疾病名称 别名
Thrombocytopenia, Anemia, And Myelofibrosis

THAMY
Myelofibrosis

Primary Myelofibrosis

Agnogenic Myeloid Metaplasia

Idiopathic Myelofibrosis

Myeloid Metaplasia

Myelofibrosis With Myeloid Metaplasia

Osteomyelofibrosis

Megakaryocytic Myelosclerosis

Myelosclerosis

Chronic Idiopathic Myelofibrosis

Myelofibrosis, Idiopathic

Myelofibrosis With Myeloid Metaplasia, Somatic

Myelofibrosis, Somatic

Aleukemic Myelosis

Bone Marrow Fibrosis

MYELOF

MMM

Agnogenic Myeloid Metaplasia With Myelofibrosis

Ammm

Myelosclerosis With Myeloid Metaplasia

Myelofibrosis Nos
Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency

GPS

Bdplt4

Bleeding Disorder, Platelet-Type, 4

Grey Platelet Syndrome

Platelet-Type Bleeding Disorder 4

Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins

Deficient Alpha Granule Syndrome

Platelet Alpha Granule Deficiency

Platelet Granule Defect

Alpha Storage Pool Deficiency

Bleeding Disorder Platelet-Type 4
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Pseudo-Von Willebrand Disease

Bdplt3

Von Willebrand Disease, Platelet-Type

VWDP

Platelet-Type Bleeding Disorder 3

Platelet Type-Von Willebrand Disease

Pt-Vwd

Von Willebrand Disease Platelet-Type

Von Willebrand Disease, Platelet Type

Pseudo Von Willebrand Disease

Bleeding Disorder, Platelet-Type, 3

Pseudo-Von Willebrand Disease Type 2b

Bleeding Disorder Platelet-Type 3

Pseudo-Vwd
Pancytopenia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08615 MPIG6B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MPIG6B RGD RGD:1303269
Bos taurus MPIG6B VGNC VGNC:31577
Felis catus MPIG6B VGNC VGNC:63572
Mus musculus MPIG6B MGD MGI:2146995
Macaca mulatta MPIG6B VGNC VGNC:74736
Canis familiaris MPIG6B VGNC VGNC:49683
Others MPIG6B NCBI
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