ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Gene

中文名称：ST8 α-N-乙酰神经氨酸 α-2,8-唾液酸转移酶 2

种属: Homo sapiens

同用名: STX; SIAT8B; SIAT8-B; HsT19690; ST8SiaII; ST8SIA-II

基因 ID: 8128 | 基因类型: protein coding

关于 ST8SIA2

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:92,393,881-92,468,728 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 5 paralogues. Biased expression in heart (RPKM 1.6), brain (RPKM 0.9) and 4 other tissues.

功能概要

该基因编码的蛋白质是一种 II 型膜蛋白，被认为可催化唾液酸从 CMP-唾液酸转移到 N-连接的寡糖和糖蛋白。编码的蛋白质可能存在于高尔基体中，并且可能参与聚唾液酸的产生，聚唾液酸是神经细胞粘附分子 (NCAM1) 粘附特性的调节剂。该蛋白质是糖基转移酶家族 29 的成员。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of Glycosyltransferase family 29. [provided by RefSeq, Jul 2008]

ST8SIA2 基因产物(2)

mRNA	Protein	Name
NM_001330416.2	NP_001317345.1	alpha-2,8-sialyltransferase 8B isoform 2 precursor
NM_006011.4	NP_006002.1	alpha-2,8-sialyltransferase 8B isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IDA IDA: 通过直接分析推断	9774483	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in N-glycan processing	IDA IDA: 通过直接分析推断	10766765	GOA
involved in ganglioside biosynthetic process	IDA IDA: 通过直接分析推断	10766765	GOA
involved in oligosaccharide metabolic process	IDA IDA: 通过直接分析推断	10766765	GOA
involved in protein glycosylation	IDA IDA: 通过直接分析推断	10766765	GOA
involved in sialylation	IDA IDA: 通过直接分析推断	7559389	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	9852130	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	11744634	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST8SIA2 蛋白结构

Glyco_transf_29

0
100
200
300
375 a.a.

蛋白主名

其他名称

alpha-2,8-sialyltransferase 8B

ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2

关联疾病

疾病名称

别名

Acute Diarrhea

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Dysentery

Infectious Diarrhea

Osteogenesis Imperfecta, Type Xx

OI20	Osteogenesis Imperfecta Type 20
Osteogenesis Imperfecta, Type 20	Osteogenesis Imperfecta Type Xx
Osteogenesis Imperfecta 20

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Visual Pathway Disease

Disorder Of Visual Pathways

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Cortical Blindness

Blindness, Cortical

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式 Pre-designed Sets	纯度	是否罕见病否
HY-RS13857	ST8SIA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ST8SIA2	VGNC	VGNC:46865
Macaca mulatta	ST8SIA2	VGNC	VGNC:77831
Felis catus	ST8SIA2	VGNC	VGNC:65736
Mus musculus	ST8SIA2	MGD	MGI:106020
Rattus norvegicus	ST8SIA2	RGD	RGD:621843
Bos taurus	ST8SIA2	VGNC	VGNC:35344

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