1. Gene
  2. OR51E2 - olfactory receptor family 51 subfamily E member 2 Gene

OR51E2 - olfactory receptor family 51 subfamily E member 2 Gene

中文名称:嗅觉受体家族 51 亚家族 E 成员 2

种属: Homo sapiens

同用名: PSGR; HPRAJ; OR52A2; OR51E3P

基因 ID: 81285 | 基因类型: protein coding

关于 OR51E2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,680,171-4,697,853 (from NCBI)

This gene has 3 transcripts (splice variants), 108 orthologues and 51 paralogues. Biased expression in prostate (RPKM 29.8) and placenta (RPKM 2.3).

功能概要

嗅觉受体与鼻子中的气味分子相互作用,引发神经元反应,从而触发对气味的感知。嗅觉受体蛋白是来自单个编码外显子基因的 G 蛋白偶联受体 (GPCR) 大家族的成员。嗅觉受体与许多神经递质和激素受体共享一个 7 跨膜结构域,负责气味信号的识别和 G 蛋白介导的转导。嗅觉受体基因家族是基因组中最大的。分配给该生物体的嗅觉受体基因和蛋白质的命名法独立于其他生物体。[RefSeq 提供,2008 年 7 月]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory Receptor Proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of Other organisms. [provided by RefSeq, Jul 2008]

OR51E2 基因产物(1)

mRNA Protein Name
NM_030774.4 NP_110401.1 olfactory receptor 5.10E+03
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear steroid receptor activity IDA
IDA: 通过直接分析推断
19389702 GOA
enables olfactory receptor activity IDA
IDA: 通过直接分析推断
19389702 GOA
enables olfactory receptor activity IMP
IMP: 通过突变表型推断
29249973 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
29249973 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
29249973 GOA
involved in melanocyte differentiation IMP
IMP: 通过突变表型推断
27226631 GOA
involved in melanocyte proliferation IMP
IMP: 通过突变表型推断
27226631 GOA
involved in steroid hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
19389702 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome membrane IDA
IDA: 通过直接分析推断
27226631 GOA
located in intracellular organelle IDA
IDA: 通过直接分析推断
29249973 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23401498 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OR51E2 蛋白结构

7tm_4

7tm_4: Olfactory receptor (145 - 284)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
蛋白主名 其他名称

olfactory receptor 51E2

olfactory receptor OR11-16

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus OR51E2 VGNC VGNC:101075
Rattus norvegicus OR51E2 RGD RGD:628858
Canis familiaris OR51E2 VGNC VGNC:97040
Mus musculus OR51E2 MGD MGI:2157548