Bdkrb1 - bradykinin receptor B1 Gene

中文名称：缓激肽受体 B1

种属: Rattus norvegicus

同用名: BKR; Bdkrb; b1bkr

关于 Bdkrb1

功能概要

该基因编码的蛋白可启动缓激肽受体活性和肽结合活性。参与多个过程，包括正调节螯合钙离子释放到胞质溶胶中；蛋白激酶C激活G蛋白偶联受体信号通路；和对脂多糖的反应。位于神经元投射和质膜。用于研究糖尿病血管病；癫痫;高血压;神经病（多发）；和胸膜炎。糖尿病视网膜病变的生物标志物；高血压;和心肌梗塞。该基因的人类直系同源物与终末期肾病有关；高血压;和肺纤维化。与人 BDKRB1（缓激肽受体 B1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Bradykinin Receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Located in neuron projection and plasma membrane. Used to study diabetic angiopathy; epilepsy; hypertension; neuropathy (multiple); and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (Bradykinin Receptor B1). [provided by Alliance of Genome Resources, Apr 2022]