Ppargc1a - PPARG coactivator 1 alpha Gene

中文名称：PPARG 共激活因子 1α

种属: Rattus norvegicus

同用名: PGCvf; LRPGC1; PGC-1v; PGCvf1; PGCvf-1; Ppargc1

关于 Ppargc1a

功能概要

该基因编码的蛋白可启动多种功能，包括α-微管蛋白结合活性；雌激素受体结合活性；和过氧化物酶体增殖物激活受体结合活性。参与多个过程，包括细胞对己糖刺激的反应；细胞对有机环状化合物的反应；和调节平滑肌细胞增殖。位于多个细胞成分中，包括顶端树突；胞质核糖体；和常染色质。用于研究多种疾病，包括脂肪肝（多发性）；糖代谢疾病（多种）；心脏病（多种）；神经退行性疾病（多种）；和坐骨神经病。多种疾病的生物标志物，包括亨廷顿舞蹈病；糖代谢疾病（多种）；胎盘功能不全;原发性胆汁性胆管炎;和肾纤维化。该基因的人类直系同源物与多种疾病有关，包括黄斑变性；恶性纤维组织细胞瘤；神经退行性疾病（多种）；非酒精性脂肪肝病；和 2 型糖尿病。与人 PPARGC1A（PPARG 辅激活因子 1 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including alpha-tubulin binding activity; Estrogen Receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); placental insufficiency; primary biliary cholangitis; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]