H3C2 - H3 clustered histone 2 Gene

中文名称：H3 成簇组蛋白 2

种属: Homo sapiens

同用名: H3/l; H3C1; H3C3; H3C4; H3C6; H3C7; H3C8; H3FL; H3C10; H3C11; H3C12; HIST1H3B

基因 ID: 8358 | 基因类型: protein coding

关于 H3C2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,031,589-26,032,099 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 20 paralogues and is associated with 53 phenotypes.

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。这种结构由大约 146 bp 的 DNA 组成，核小体是一个八聚体，由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H3 家族的成员。该基因的转录本缺少 polyA 尾巴；相反，它们包含回文终止元素。该基因存在于染色体 6p22-p21.3 上的大组蛋白基因簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C2 基因产物(1)

mRNA	Protein	Name
NM_003537.4	NP_003528.1	histone H3.1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IDA IDA: 通过直接分析推断	30867594	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10949293	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epigenetic regulation of gene expression	IDA IDA: 通过直接分析推断	16267050	GOA
acts upstream of positive effect gene expression	IDA IDA: 通过直接分析推断	30867594	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	14718166	GOA
involved in nucleosome assembly	IMP IMP: 通过突变表型推断	25615412	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of nucleosome	IDA IDA: 通过直接分析推断	14718166	GOA
part of nucleosome	IPI IPI: 通过物理相互作用推断	21812398	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21636898	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	14718166	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H3C2 蛋白结构

Histone

0
100
136 a.a.

蛋白主名

其他名称

histone H3.1

H3 histone family, member L

重组 H3C2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72332	Histone H3 Protein, Human	P68431 (A2-A136)	≥95%
HY-P72335	Histone H3 Protein, Human (98a.a, His)	P68431 (P39-A136)	≥95%
HY-P72798	Histone H3 Protein, Human (His)	P68431 (A2-A136)	≥95%

关联疾病

疾病名称

别名

Hematologic Cancer

Hematologic Neoplasm	Hematologic Neoplasms
Hematologic Malignancies	Blood Cancer
Hematologic Malignancy	Hematological Tumors
Hematopoietic And Lymphoid System Tumor	Hematopoietic Cancer
Hematopoietic Neoplasm	Hematopoietic Tumors
Malignant Hematopoietic Neoplasm	Liquid Tumor
Hematopoietic Neoplasms

Histone Mutated Tumor

Histone Mutated Tumour

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Adult Infiltrating Astrocytic Neoplasm

Adult Infiltrating Astrocytoma

Adult Infiltrating Astrocytic Tumor

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Brain Stem Glioma

Brainstem Glioma	Brainstem Neuroglial Tumor
Glioma Of Brainstem

Posterior Fossa Ependymoma

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Idh-Wildtype Glioblastoma

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Diffuse Astrocytoma

Diffuse Astrocytoma, Low Grade	Who Grade Ii Astrocytoma
Fibrillary Astrocytoma	Gemistocytic Astrocytoma
Low-Grade Diffuse Astrocytoma	Protoplasmic Astrocytoma

Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

Pilomyxoid Astrocytoma

Anaplastic Oligodendroglioma

Low Grade Glioma

Benign Glioma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05968	H3C2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	H3C2	MGD	MGI:2448319

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

H3C2 - H3 clustered histone 2 Gene

关于 H3C2

功能概要

H3C2 基因产物(1)

H3C2 蛋白结构

重组 H3C2 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

H3C2 - H3 clustered histone 2 Gene

关于 H3C2

功能概要

H3C2 基因产物(1)

H3C2 蛋白结构

重组 H3C2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z