Nfe2l2 - NFE2 like bZIP transcription factor 2 Gene

中文名称：NFE2 样 bZ IP 转录因子 2

种属: Rattus norvegicus

关于 Nfe2l2

功能概要

该基因编码的蛋白可启动转录顺式调节区结合活性和转录共调节因子结合活性。参与多个过程，包括黄曲霉毒素分解代谢过程；大分子代谢过程的正向调控；和细胞迁移的调节。位于细胞质和细胞核中。用于研究多种疾病，包括糖尿病视网膜病变；肝硬化;大脑中动脉梗塞;非酒精性脂肪肝病；和视觉性癫痫。多种疾病的生物标志物，包括肝外胆汁淤积；肾功能衰竭（多发）；神经退行性疾病（多种）；非酒精性脂肪性肝炎；和 2 型糖尿病。该基因的人类直系同源物与阿尔茨海默病有关；白内障;肝细胞癌；黄斑变性;和肺结核。与人类 NFE2L2 同源（NFE2 像 bZIP 转录因子 2）。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]