Ctnnb1 - catenin beta 1 Gene

中文名称：连环蛋白 1

种属: Rattus norvegicus

同用名: Catnb

关于 Ctnnb1

功能概要

该基因编码的蛋白可启动钙粘蛋白结合活动；离子型谷氨酸受体结合活性；和一氧化氮合酶结合活性。参与多个过程，包括细胞对胰岛素样生长因子刺激的反应；细胞对锂离子的反应；和细胞对机械刺激的反应。位于多个细胞成分中，包括树突状轴；闰盘;和核膜。部分含蛋白质复合物。与神经元投射共定位。用于研究结肠腺癌和肺癌。阿尔茨海默病和结直肠癌的生物标志物。该基因的人类直系同源物与多种疾病有关，包括常染色体显性非综合征性智力障碍 19；渗出性玻璃体视网膜病变 7；肝细胞癌（多发性）；生殖器官癌（多发性）；和泌尿系统癌症（多发性）。与人类 CTNNB1（连环蛋白 beta 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cadherin binding activity; ionotropic glutamate receptor binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and nuclear membrane. Part of protein-containing complex. Colocalizes with neuron projection. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal Cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ Cancer (multiple); and urinary system Cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Apr 2022]