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  2. GPR174 - G protein-coupled receptor 174 Gene

GPR174 - G protein-coupled receptor 174 Gene

中文名称:G 蛋白偶联受体 174

种属: Homo sapiens

同用名: FKSG79; GPCR17; LYPSR3

基因 ID: 84636 | 基因类型: protein coding

关于 GPR174

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:79,144,688-79,175,318 (from NCBI)

This gene has 1 transcript (splice variant), 95 orthologues and 7 paralogues.

功能概要

该基因编码属于 G 蛋白偶联受体超家族的一种蛋白质。这些蛋白质的特点是存在七个 α 螺旋跨膜结构域,它们激活各种内源性或外源性配体或与之相互作用,包括神经递质、激素以及气味和味觉物质。该家族成员被归类为孤儿受体,因为尚未鉴定同源配体。[RefSeq 提供,2011 年 9 月]

This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, Hormones, and odorant and taste substances. This family member is classified as an Orphan Receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GPR174 基因产物(1)

mRNA Protein Name
NM_032553.3 NP_115942.1 probable G-protein coupled receptor 174
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
36823105 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of interleukin-2 production IDA
IDA: 通过直接分析推断
29457279 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR174 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 292)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 174

关联疾病

疾病名称 别名
Hypertensive Retinopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GPR174 RGD RGD:1564689
Bos taurus GPR174 VGNC VGNC:29571
Canis familiaris GPR174 VGNC VGNC:41417
Mus musculus GPR174 MGD MGI:2685222
Felis catus GPR174 VGNC VGNC:62688