2. Gene
  3. PLA2G12B - phospholipase A2 group XIIB Gene

PLA2G12B - phospholipase A2 group XIIB Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 A2 XIIB 组

种属: Homo sapiens

同用名: GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB

基因 ID: 84647 | 基因类型: protein coding

关于 PLA2G12B

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,934,762-72,954,806 (from NCBI)

This gene has 1 transcript (splice variant), 271 orthologues and 1 paralogue. Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues.

功能概要

该基因编码的蛋白质属于磷脂酶 A2 (PLA2) 酶类，其在糖脂水解中发挥作用，释放游离脂肪酸和溶血磷脂。该家族成员改变了磷脂结合特性并且没有催化活性。该蛋白被分泌，并与微粒体甘油三酯转移蛋白一起发挥调节 HNF4alpha 诱导的丙型肝炎病毒感染性的作用。该基因的表达在各种肿瘤中被下调，表明它可能作为肿瘤进展的负调节因子发挥作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene belongs to the Phospholipase A2 (PLA2) group of Enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

PLA2G12B 基因产物(3)

mRNA Protein Name
NM_001318124.2 NP_001305053.1 group XIIB secretory phospholipase A2-like protein isoform b precursor
NM_001318125.2 NP_001305054.1 group XIIB secretory phospholipase A2-like protein isoform c
NM_032562.5 NP_115951.2 group XIIB secretory phospholipase A2-like protein isoform a precursor

PLA2G12B 蛋白结构

PLA2G12

PLA2G12: Group XII secretory phospholipase A2 precursor (PLA2G12) (14 - 195)

  • 0
  • 100
  • 195 a.a.
蛋白主名 其他名称

group XIIB secretory phospholipase A2-like protein

group XIII secreted phospholipase A2

关联疾病

疾病名称 别名
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Spastic Paraplegia 39, Autosomal Recessive

SPG39

Ntemnd

Hereditary Spastic Paraplegia 39

Nte-Related Motor Neuron Disorder

Autosomal Recessive Spastic Paraplegia Type 39

Spastic Paraplegia Due To Neuropathy Target Esterase Mutation

Spastic Paraplegia Due To Nte Mutation

Spastic Paraplegia 39

Autosomal Recessive Spastic Paraplegia 39

Nte Related Motor Neuron Disorder

Paraplegia, Spastic, Type 39
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10618 PLA2G12B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLA2G12B RGD RGD:1588484
Bos taurus PLA2G12B VGNC VGNC:32955
Macaca mulatta PLA2G12B VGNC VGNC:76059
Mus musculus PLA2G12B MGD MGI:1917086
Canis familiaris PLA2G12B VGNC VGNC:44620
Others PLA2G12B NCBI
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