2. Gene
  3. TOX2 - TOX high mobility group box family member 2 Gene

TOX2 - TOX high mobility group box family member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TOX 高机动性组盒家族成员 2

种属: Homo sapiens

同用名: GCX1; GCX-1; C20orf100; dJ495O3.1; dJ1108D11.2

基因 ID: 84969 | 基因类型: protein coding

关于 TOX2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,914,852-44,069,616 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 20 paralogues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 4.6) and 21 other tissues.

功能概要

启用转录共激活因子活性。参与 RNA 聚合酶 II 对转录的正调控。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TOX2 基因产物(4)

mRNA Protein Name
NM_001098796.2 NP_001092266.1 TOX high mobility group box family member 2 isoform c
NM_001098797.2 NP_001092267.1 TOX high mobility group box family member 2 isoform a
NM_001098798.2 NP_001092268.1 TOX high mobility group box family member 2 isoform b
NM_032883.3 NP_116272.1 TOX high mobility group box family member 2 isoform c
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
25352127 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
25352127 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOX2 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (255 - 302)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

TOX high mobility group box family member 2

granulosa cell HMG box 1

关联疾病

疾病名称 别名
Conduct Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14909 TOX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TOX2 VGNC VGNC:47718
Bos taurus TOX2 VGNC VGNC:55084
Felis catus TOX2 VGNC VGNC:66459
Rattus norvegicus TOX2 RGD RGD:735184
Mus musculus TOX2 MGD MGI:3611233
Macaca mulatta TOX2 VGNC VGNC:79007
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